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Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist

BACKGROUND: Inhaled lipopolysaccharide (LPS) induces a dose-dependent, acute neutrophilic response in the airways of healthy volunteers that can be quantified in induced sputum. Chemokines, such as CXCL1 and CXCL8, play an important role in neutrophilic inflammation in the lung through the activatio...

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Detalles Bibliográficos
Autores principales:	Leaker, Brian R, Barnes, Peter J, O’Connor, Brian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867427/ https://www.ncbi.nlm.nih.gov/pubmed/24341382 http://dx.doi.org/10.1186/1465-9921-14-137

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