Cargando…

Effects of Troponin T Cardiomyopathy Mutations on the Calcium Sensitivity of the Regulated Thin Filament and the Actomyosin Cross-Bridge Kinetics of Human β-Cardiac Myosin

Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) lead to significant cardiovascular morbidity and mortality worldwide. Mutations in the genes encoding the sarcomere, the force-generating unit in the cardiomyocyte, cause familial forms of both HCM and DCM. This study examines two HC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sommese, Ruth F., Nag, Suman, Sutton, Shirley, Miller, Susan M., Spudich, James A., Ruppel, Kathleen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867432/ https://www.ncbi.nlm.nih.gov/pubmed/24367593 http://dx.doi.org/10.1371/journal.pone.0083403

Ejemplares similares

Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin
por: Pan, Stephen, et al.
Publicado: (2015)

Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function
por: Nag, Suman, et al.
Publicado: (2015)

Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules
por: Sung, Jongmin, et al.
Publicado: (2015)

A troponin T variant linked with pediatric dilated cardiomyopathy reduces the coupling of thin filament activation to myosin and calcium binding
por: Barrick, Samantha K., et al.
Publicado: (2021)

Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy
por: Kawana, Masataka, et al.
Publicado: (2017)

Cardiac myosin filaments are directly regulated by calcium
por: Ma, Weikang, et al.
Publicado: (2022)

Myosin and gelsolin cooperate in actin filament severing and actomyosin motor activity
por: Vemula, Venukumar, et al.
Publicado: (2020)

Dictyostelium Myosin Bipolar Thick Filament Formation: Importance of Charge and Specific Domains of the Myosin Rod
por: Hostetter, Daniel, et al.
Publicado: (2004)

Correction: Dictyostelium Myosin Bipolar Thick Filament Formation: Importance of Charge and Specific Domains of the Myosin Rod
por: Hostetter, Daniel, et al.
Publicado: (2005)

Structure and Orientation of Troponin in the Thin Filament
por: Paul, Danielle M., et al.
Publicado: (2009)

Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light
por: Trivedi, Darshan V., et al.
Publicado: (2017)

Controlling load-dependent kinetics of β-cardiac myosin at the single molecule level
por: Liu, Chao, et al.
Publicado: (2018)

Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector
por: Aksel, Tural, et al.
Publicado: (2015)

Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function
por: Morck, Makenna M, et al.
Publicado: (2022)

Interactions of Desensitized Actomyosin with Tropomyosin, Troponin A, Troponin B, and Polyanions
por: Hartshorne, D. J.
Publicado: (1970)

Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila
por: Trujillo, Adriana S., et al.
Publicado: (2021)

Myosin turnover controls actomyosin contractile instability
por: Thiyagarajan, Sathish, et al.
Publicado: (2022)

Kinetics of a Ca(2+)-sensitive cross-bridge state transition in skeletal muscle fibers. Effects due to variations in thin filament activation by extraction of troponin C
Publicado: (1991)

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
por: Adhikari, Arjun S., et al.
Publicado: (2019)

The R403Q Myosin Mutation Implicated in Familial Hypertrophic Cardiomyopathy Causes Disorder at the Actomyosin Interface
por: Volkmann, Niels, et al.
Publicado: (2007)

Facilitated Cross-Bridge Interactions with Thin Filaments by Familial Hypertrophic Cardiomyopathy Mutations in α-Tropomyosin
por: Wang, Fang, et al.
Publicado: (2011)

A STUDY OF THE ADENOSINE TRIPHOSPHATASE ACTIVITY OF MYOSIN AND ACTOMYOSIN
por: Mommaerts, W. F. H. M., et al.
Publicado: (1947)

Resting myosin cross-bridge configuration in frog muscle thick filaments
Publicado: (1986)

Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing
por: Park-Holohan, So-Jin, et al.
Publicado: (2021)

Micromechanical Thermal Assays of Ca(2+)-Regulated Thin-Filament Function and Modulation by Hypertrophic Cardiomyopathy Mutants of Human Cardiac Troponin
por: Brunet, Nicolas M., et al.
Publicado: (2012)

A Structural Model for Phosphorylation Control of Dictyostelium Myosin II Thick Filament Assembly
por: Liang, Wenchuan, et al.
Publicado: (1999)

Using Fluorescent Myosin to Directly Visualize Cooperative Activation of Thin Filaments
por: Desai, Rama, et al.
Publicado: (2015)

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin
por: Sarkar, Saswata S., et al.
Publicado: (2020)

3-D structural analysis of the crucial intermediate of skeletal muscle myosin and its role in revised actomyosin cross-bridge cycle
por: Katayama, Eisaku
Publicado: (2014)

Myosin essential light chain 1sa decelerates actin and thin filament gliding on β-myosin molecules
por: Osten, Jennifer, et al.
Publicado: (2022)

Hypertrophic cardiomyopathy: Mutations to mechanisms to therapies
por: Kawana, Masataka, et al.
Publicado: (2022)

The force of the myosin motor sets cooperativity in thin filament activation of skeletal muscles
por: Caremani, Marco, et al.
Publicado: (2022)

Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle
por: Caremani, Marco, et al.
Publicado: (2023)

High-resolution structures of malaria parasite actomyosin and actin filaments
por: Vahokoski, Juha, et al.
Publicado: (2022)

Electron microscopy of synthetic myosin filaments. Evidence for cross- bridge. Flexibility and copolymer formation
Publicado: (1975)

Modulation of Thin Filament Activation of Myosin ATP Hydrolysis by N-Terminal Domains of Cardiac Myosin Binding Protein-C
por: Belknap, Betty, et al.
Publicado: (2014)

Lamin A/C deficiency enables increased myosin-II bipolar filament ensembles that promote divergent actomyosin network anomalies through self-organization
por: Wiggan, O’Neil, et al.
Publicado: (2020)

Single-molecule imaging reveals the concerted release of myosin from regulated thin filaments
por: Smith, Quentin M, et al.
Publicado: (2021)

Actin-facilitated assembly of smooth muscle myosin induces formation of actomyosin fibrils
Publicado: (1992)

Myosin Binding Protein-C: A Regulator of Actomyosin Interaction in Striated Muscle
por: Ackermann, Maegen A., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_st8frv2h4rf88dhts2ea45e5ub