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Effects of Troponin T Cardiomyopathy Mutations on the Calcium Sensitivity of the Regulated Thin Filament and the Actomyosin Cross-Bridge Kinetics of Human β-Cardiac Myosin

Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) lead to significant cardiovascular morbidity and mortality worldwide. Mutations in the genes encoding the sarcomere, the force-generating unit in the cardiomyocyte, cause familial forms of both HCM and DCM. This study examines two HC...

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Detalles Bibliográficos
Autores principales:	Sommese, Ruth F., Nag, Suman, Sutton, Shirley, Miller, Susan M., Spudich, James A., Ruppel, Kathleen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867432/ https://www.ncbi.nlm.nih.gov/pubmed/24367593 http://dx.doi.org/10.1371/journal.pone.0083403

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