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Stress adaptation in a pathogenic fungus

Candida albicans is a major fungal pathogen of humans. This yeast is carried by many individuals as a harmless commensal, but when immune defences are perturbed it causes mucosal infections (thrush). Additionally, when the immune system becomes severely compromised, C. albicans often causes life-thr...

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Autores principales: Brown, Alistair J. P., Budge, Susan, Kaloriti, Despoina, Tillmann, Anna, Jacobsen, Mette D., Yin, Zhikang, Ene, Iuliana V., Bohovych, Iryna, Sandai, Doblin, Kastora, Stavroula, Potrykus, Joanna, Ballou, Elizabeth R., Childers, Delma S., Shahana, Shahida, Leach, Michelle D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Company of Biologists 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867497/
https://www.ncbi.nlm.nih.gov/pubmed/24353214
http://dx.doi.org/10.1242/jeb.088930
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author Brown, Alistair J. P.
Budge, Susan
Kaloriti, Despoina
Tillmann, Anna
Jacobsen, Mette D.
Yin, Zhikang
Ene, Iuliana V.
Bohovych, Iryna
Sandai, Doblin
Kastora, Stavroula
Potrykus, Joanna
Ballou, Elizabeth R.
Childers, Delma S.
Shahana, Shahida
Leach, Michelle D.
author_facet Brown, Alistair J. P.
Budge, Susan
Kaloriti, Despoina
Tillmann, Anna
Jacobsen, Mette D.
Yin, Zhikang
Ene, Iuliana V.
Bohovych, Iryna
Sandai, Doblin
Kastora, Stavroula
Potrykus, Joanna
Ballou, Elizabeth R.
Childers, Delma S.
Shahana, Shahida
Leach, Michelle D.
author_sort Brown, Alistair J. P.
collection PubMed
description Candida albicans is a major fungal pathogen of humans. This yeast is carried by many individuals as a harmless commensal, but when immune defences are perturbed it causes mucosal infections (thrush). Additionally, when the immune system becomes severely compromised, C. albicans often causes life-threatening systemic infections. A battery of virulence factors and fitness attributes promote the pathogenicity of C. albicans. Fitness attributes include robust responses to local environmental stresses, the inactivation of which attenuates virulence. Stress signalling pathways in C. albicans include evolutionarily conserved modules. However, there has been rewiring of some stress regulatory circuitry such that the roles of a number of regulators in C. albicans have diverged relative to the benign model yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. This reflects the specific evolution of C. albicans as an opportunistic pathogen obligately associated with warm-blooded animals, compared with other yeasts that are found across diverse environmental niches. Our understanding of C. albicans stress signalling is based primarily on the in vitro responses of glucose-grown cells to individual stresses. However, in vivo this pathogen occupies complex and dynamic host niches characterised by alternative carbon sources and simultaneous exposure to combinations of stresses (rather than individual stresses). It has become apparent that changes in carbon source strongly influence stress resistance, and that some combinatorial stresses exert non-additive effects upon C. albicans. These effects, which are relevant to fungus–host interactions during disease progression, are mediated by multiple mechanisms that include signalling and chemical crosstalk, stress pathway interference and a biological transistor.
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spelling pubmed-38674972014-07-01 Stress adaptation in a pathogenic fungus Brown, Alistair J. P. Budge, Susan Kaloriti, Despoina Tillmann, Anna Jacobsen, Mette D. Yin, Zhikang Ene, Iuliana V. Bohovych, Iryna Sandai, Doblin Kastora, Stavroula Potrykus, Joanna Ballou, Elizabeth R. Childers, Delma S. Shahana, Shahida Leach, Michelle D. J Exp Biol Cellular Stress Candida albicans is a major fungal pathogen of humans. This yeast is carried by many individuals as a harmless commensal, but when immune defences are perturbed it causes mucosal infections (thrush). Additionally, when the immune system becomes severely compromised, C. albicans often causes life-threatening systemic infections. A battery of virulence factors and fitness attributes promote the pathogenicity of C. albicans. Fitness attributes include robust responses to local environmental stresses, the inactivation of which attenuates virulence. Stress signalling pathways in C. albicans include evolutionarily conserved modules. However, there has been rewiring of some stress regulatory circuitry such that the roles of a number of regulators in C. albicans have diverged relative to the benign model yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. This reflects the specific evolution of C. albicans as an opportunistic pathogen obligately associated with warm-blooded animals, compared with other yeasts that are found across diverse environmental niches. Our understanding of C. albicans stress signalling is based primarily on the in vitro responses of glucose-grown cells to individual stresses. However, in vivo this pathogen occupies complex and dynamic host niches characterised by alternative carbon sources and simultaneous exposure to combinations of stresses (rather than individual stresses). It has become apparent that changes in carbon source strongly influence stress resistance, and that some combinatorial stresses exert non-additive effects upon C. albicans. These effects, which are relevant to fungus–host interactions during disease progression, are mediated by multiple mechanisms that include signalling and chemical crosstalk, stress pathway interference and a biological transistor. Company of Biologists 2014-01-01 /pmc/articles/PMC3867497/ /pubmed/24353214 http://dx.doi.org/10.1242/jeb.088930 Text en © 2014. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by-nc-sa/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Cellular Stress
Brown, Alistair J. P.
Budge, Susan
Kaloriti, Despoina
Tillmann, Anna
Jacobsen, Mette D.
Yin, Zhikang
Ene, Iuliana V.
Bohovych, Iryna
Sandai, Doblin
Kastora, Stavroula
Potrykus, Joanna
Ballou, Elizabeth R.
Childers, Delma S.
Shahana, Shahida
Leach, Michelle D.
Stress adaptation in a pathogenic fungus
title Stress adaptation in a pathogenic fungus
title_full Stress adaptation in a pathogenic fungus
title_fullStr Stress adaptation in a pathogenic fungus
title_full_unstemmed Stress adaptation in a pathogenic fungus
title_short Stress adaptation in a pathogenic fungus
title_sort stress adaptation in a pathogenic fungus
topic Cellular Stress
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867497/
https://www.ncbi.nlm.nih.gov/pubmed/24353214
http://dx.doi.org/10.1242/jeb.088930
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