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A Systematic Review of Risk Factors Associated with Surgical Site Infections among Surgical Patients
IMPORTANCE: Surgical site infection (SSI) complicates 2-5% of surgeries in the United States. Severity of SSI ranges from superficial skin infection to life-threatening conditions such as severe sepsis, and SSIs are responsible for increased morbidity, mortality, and economic burden associated with...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867498/ https://www.ncbi.nlm.nih.gov/pubmed/24367612 http://dx.doi.org/10.1371/journal.pone.0083743 |
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author | Korol, Ellen Johnston, Karissa Waser, Nathalie Sifakis, Frangiscos Jafri, Hasan S. Lo, Mathew Kyaw, Moe H. |
author_facet | Korol, Ellen Johnston, Karissa Waser, Nathalie Sifakis, Frangiscos Jafri, Hasan S. Lo, Mathew Kyaw, Moe H. |
author_sort | Korol, Ellen |
collection | PubMed |
description | IMPORTANCE: Surgical site infection (SSI) complicates 2-5% of surgeries in the United States. Severity of SSI ranges from superficial skin infection to life-threatening conditions such as severe sepsis, and SSIs are responsible for increased morbidity, mortality, and economic burden associated with surgery. Staphylococcus aureus (S. aureus) is a commonly-isolated organism for SSI, and methicillin-resistant S. aureus SSI incidence is increasing globally. OBJECTIVE: The objective of this systematic review was to characterize risk factors for SSI within observational studies describing incidence of SSI in a real-world setting. EVIDENCE REVIEW: An initial search identified 328 titles published in 2002-2012; 57 were identified as relevant for data extraction. Extracted information included study design and methodology, reported cumulative incidence and post-surgical time until onset of SSI, and odds ratios and associated variability for all factors considered in univariate and/or multivariable analyses. FINDINGS: Median SSI incidence was 3.7%, ranging from 0.1% to 50.4%. Incidence of overall SSI and S. aureus SSI were both highest in tumor-related and transplant surgeries. Median time until SSI onset was 17.0 days, with longer time-to-onset for orthopedic and transplant surgeries. Risk factors consistently identified as associated with SSI included co-morbidities, advanced age, risk indices, patient frailty, and surgery complexity. Thirteen studies considered diabetes as a risk factor in multivariable analysis; 85% found a significant association with SSI, with odds ratios ranging from 1.5-24.3. Longer surgeries were associated with increased SSI risk, with a median odds ratio of 2.3 across 11 studies reporting significant results. CONCLUSIONS AND RELEVANCE: In a broad review of published literature, risk factors for SSI were characterized as describing reduced fitness, patient frailty, surgery duration, and complexity. Recognition of risk factors frequently associated with SSI allows for identification of such patients with the greatest need for optimal preventive measures to be identified and pre-treatment prior to surgery. |
format | Online Article Text |
id | pubmed-3867498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38674982013-12-23 A Systematic Review of Risk Factors Associated with Surgical Site Infections among Surgical Patients Korol, Ellen Johnston, Karissa Waser, Nathalie Sifakis, Frangiscos Jafri, Hasan S. Lo, Mathew Kyaw, Moe H. PLoS One Research Article IMPORTANCE: Surgical site infection (SSI) complicates 2-5% of surgeries in the United States. Severity of SSI ranges from superficial skin infection to life-threatening conditions such as severe sepsis, and SSIs are responsible for increased morbidity, mortality, and economic burden associated with surgery. Staphylococcus aureus (S. aureus) is a commonly-isolated organism for SSI, and methicillin-resistant S. aureus SSI incidence is increasing globally. OBJECTIVE: The objective of this systematic review was to characterize risk factors for SSI within observational studies describing incidence of SSI in a real-world setting. EVIDENCE REVIEW: An initial search identified 328 titles published in 2002-2012; 57 were identified as relevant for data extraction. Extracted information included study design and methodology, reported cumulative incidence and post-surgical time until onset of SSI, and odds ratios and associated variability for all factors considered in univariate and/or multivariable analyses. FINDINGS: Median SSI incidence was 3.7%, ranging from 0.1% to 50.4%. Incidence of overall SSI and S. aureus SSI were both highest in tumor-related and transplant surgeries. Median time until SSI onset was 17.0 days, with longer time-to-onset for orthopedic and transplant surgeries. Risk factors consistently identified as associated with SSI included co-morbidities, advanced age, risk indices, patient frailty, and surgery complexity. Thirteen studies considered diabetes as a risk factor in multivariable analysis; 85% found a significant association with SSI, with odds ratios ranging from 1.5-24.3. Longer surgeries were associated with increased SSI risk, with a median odds ratio of 2.3 across 11 studies reporting significant results. CONCLUSIONS AND RELEVANCE: In a broad review of published literature, risk factors for SSI were characterized as describing reduced fitness, patient frailty, surgery duration, and complexity. Recognition of risk factors frequently associated with SSI allows for identification of such patients with the greatest need for optimal preventive measures to be identified and pre-treatment prior to surgery. Public Library of Science 2013-12-18 /pmc/articles/PMC3867498/ /pubmed/24367612 http://dx.doi.org/10.1371/journal.pone.0083743 Text en © 2013 Korol et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Korol, Ellen Johnston, Karissa Waser, Nathalie Sifakis, Frangiscos Jafri, Hasan S. Lo, Mathew Kyaw, Moe H. A Systematic Review of Risk Factors Associated with Surgical Site Infections among Surgical Patients |
title | A Systematic Review of Risk Factors Associated with Surgical Site Infections among Surgical Patients |
title_full | A Systematic Review of Risk Factors Associated with Surgical Site Infections among Surgical Patients |
title_fullStr | A Systematic Review of Risk Factors Associated with Surgical Site Infections among Surgical Patients |
title_full_unstemmed | A Systematic Review of Risk Factors Associated with Surgical Site Infections among Surgical Patients |
title_short | A Systematic Review of Risk Factors Associated with Surgical Site Infections among Surgical Patients |
title_sort | systematic review of risk factors associated with surgical site infections among surgical patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867498/ https://www.ncbi.nlm.nih.gov/pubmed/24367612 http://dx.doi.org/10.1371/journal.pone.0083743 |
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