Cargando…

PEDF Expression Is Inhibited by Insulin Treatment in Adipose Tissue via Suppressing 11β-HSD1

Early intensive insulin therapy improves insulin sensitivity in type 2 diabetic patients; while the underlying mechanism remains largely unknown. Pigment epithelium-derived factor (PEDF), an anti-angiogenic factor, is believed to be involved in the pathogenesis of insulin resistance. Here, we hypoth...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Yinli, Xu, Fen, Deng, Hongrong, Bi, Yan, Sun, Weiping, Zhao, Yi, Chen, Zonglan, Weng, Jianping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867502/ https://www.ncbi.nlm.nih.gov/pubmed/24367624 http://dx.doi.org/10.1371/journal.pone.0084016

Ejemplares similares

Salicylate Downregulates 11β-HSD1 Expression in Adipose Tissue in Obese Mice and in Humans, Mediating Insulin Sensitization
por: Nixon, Mark, et al.
Publicado: (2012)

Differences in Expression, Content, and Activity of 11β-HSD1 in Adipose Tissue between Obese Men and Women
por: Torres, A., et al.
Publicado: (2012)

11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice
por: Doig, Craig L., et al.
Publicado: (2017)

Increased systemic and adipose 11β-HSD1 activity in idiopathic intracranial hypertension
por: Westgate, Connar S J, et al.
Publicado: (2022)

TNFα-mediated Hsd11b1 binding of NF-κB p65 is associated with suppression of 11β-HSD1 in muscle
por: Doig, Craig L, et al.
Publicado: (2014)

Inhibition of 11β-HSD1 Expression by Insulin in Skin: Impact for Diabetic Wound Healing
por: Brazel, Christina B., et al.
Publicado: (2020)

11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) mediates insulin resistance through JNK activation in adipocytes
por: Peng, Kesong, et al.
Publicado: (2016)

11β-HSD Types 1 and 2 in the Songbird Brain
por: Rensel, Michelle A., et al.
Publicado: (2018)

11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors Still Improve Metabolic Phenotype in Male 11β-HSD1 Knockout Mice Suggesting Off-Target Mechanisms
por: Harno, Erika, et al.
Publicado: (2013)

Yeast-based assays for screening 11β-HSD1 inhibitors
por: Vanella, Rosario, et al.
Publicado: (2016)

Macrophage 11β-HSD-1 deficiency promotes inflammatory angiogenesis
por: Zhang, Zhenguang, et al.
Publicado: (2017)

11β-HSD as a New Target in Pharmacotherapy of Metabolic Diseases
por: Kupczyk, Daria, et al.
Publicado: (2022)

Synthesis of Novel 2-(Isopropylamino)thiazol-4(5H)-one Derivatives and Their Inhibitory Activity of 11β-HSD1 and 11β-HSD2 in Aspect of Carcinogenesis Prevention
por: Kupczyk, Daria, et al.
Publicado: (2020)

Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune
por: Sun, Weiguang, et al.
Publicado: (2016)

Getting to the heart of intracellular glucocorticoid regeneration: 11β-HSD1 in the myocardium
por: Gray, Gillian A, et al.
Publicado: (2016)

Glucocorticoids and 11β-HSD1 are major regulators of intramyocellular protein metabolism
por: Morgan, Stuart A, et al.
Publicado: (2016)

Inhibition of 11β-HSD1 by Tetracyclic Triterpenoids from Euphorbia kansui
por: Guo, Jie, et al.
Publicado: (2012)

Does the Caesarean Section Impact on 11β HSD2 and Fetal Cortisol?
por: Słabuszewska-Jóżwiak, Aneta, et al.
Publicado: (2020)

Equisetin is an anti-obesity candidate through targeting 11β-HSD1
por: Xu, Zhenlu, et al.
Publicado: (2022)

11β-HSD1 participates in epileptogenesis and the associated cognitive impairment by inhibiting apoptosis in mice
por: Li, Xueying, et al.
Publicado: (2022)

Effect of Glucocorticoid and 11β-Hydroxysteroid-Dehydrogenase Type 1 (11β-HSD1) in Neurological and Psychiatric Disorders
por: Dodd, Seetal, et al.
Publicado: (2022)

Suppression of the Nrf2-Dependent Antioxidant Response by Glucocorticoids and 11β-HSD1-Mediated Glucocorticoid Activation in Hepatic Cells
por: Kratschmar, Denise V., et al.
Publicado: (2012)

11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI
por: Mylonas, Katie J, et al.
Publicado: (2017)

Pressure-Induced Alterations in PEDF and PEDF-R Expression: Implications for Neuroprotective Signaling in Glaucoma
por: Lee, Sean J, et al.
Publicado: (2015)

PEDF Is Associated with the Termination of Chondrocyte Phenotype and Catabolism of Cartilage Tissue
por: Klinger, P., et al.
Publicado: (2017)

Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice
por: Yau, Joyce L.W., et al.
Publicado: (2015)

11β-HSD1 contributes to age-related metabolic decline in male mice
por: Morgan, Stuart A, et al.
Publicado: (2022)

Detection of Urinary Exosomal HSD11B2 mRNA Expression: A Useful Novel Tool for the Diagnostic Approach of Dysfunctional 11β-HSD2-Related Hypertension
por: De Santis, Domenica, et al.
Publicado: (2021)

PEDF and PEDF-derived peptide 44mer stimulate cardiac triglyceride degradation via ATGL
por: Zhang, Hao, et al.
Publicado: (2015)

Pigment Epithelium‐Derived Factor (PEDF) Improves Ischemic Cardiac Functional Reserve Through Decreasing Hypoxic Cardiomyocyte Contractility Through PEDF Receptor (PEDF‐R)
por: Lu, Peng, et al.
Publicado: (2016)

11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
por: Hermanowski-Vosatka, Anne, et al.
Publicado: (2005)

Forebrain‐Specific Transgene Rescue of 11β‐HSD1 Associates with Impaired Spatial Memory and Reduced Hippocampal Brain‐Derived Neurotrophic Factor mRNA Levels in Aged 11β‐HSD1 Deficient Mice
por: Caughey, S., et al.
Publicado: (2017)

Corticosterone suppresses IL-1β-induced mPGE2 expression through regulation of the 11β-HSD1 bioactivity of synovial fibroblasts in vitro
por: Wei, Bo, et al.
Publicado: (2017)

Loss of 11βHSD1 enhances glycolysis, facilitates intrahepatic metastasis, and indicates poor prognosis in hepatocellular carcinoma
por: Liu, Xu, et al.
Publicado: (2015)

Variants of 11β-hydroxysteroid dehydrogenase (HSD11B) gene type 1 and 2 in Chinese obese adolescents
por: Chun, Zou Chao
Publicado: (2013)

OR09-3 11β-HSD1 Mediates a Partial Suppression of Muscle Atrophy in Chronic Inflammatory Disease in Response to Therapeutic Glucocorticoids
por: Webster, Justine, et al.
Publicado: (2019)

Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice
por: Michailidou, Zoi, et al.
Publicado: (2012)

S100A16-induced adipogenesis is associated with up-regulation of 11 β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
por: Zhang, Rihua, et al.
Publicado: (2019)

The Role of PEDF in Reproductive Aging of the Ovary †
por: Nemerovsky, Luba, et al.
Publicado: (2022)

PEDF Inhibits the Activation of NLRP3 Inflammasome in Hypoxia Cardiomyocytes through PEDF Receptor/Phospholipase A2
por: Zhou, Zhongxin, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ujk9b6d6gvem9c03i7hp1lafqm