A Linear Combination of Pharmacophore Hypotheses as a New Tool in Search of New Active Compounds – An Application for 5-HT(1A) Receptor Ligands

This study explores a new approach to pharmacophore screening involving the use of an optimized linear combination of models instead of a single hypothesis. The implementation and evaluation of the developed methodology are performed for a complete known chemical space of 5-HT(1A)R ligands (3616 act...

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Detalles Bibliográficos
Autores principales: Warszycki, Dawid, Mordalski, Stefan, Kristiansen, Kurt, Kafel, Rafał, Sylte, Ingebrigt, Chilmonczyk, Zdzisław, Bojarski, Andrzej J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867515/
https://www.ncbi.nlm.nih.gov/pubmed/24367669
http://dx.doi.org/10.1371/journal.pone.0084510

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