GABAergic dysfunction in pediatric neuro-developmental disorders

The GABAergic system is central to the development and functional maturation of the nervous system. Emerging evidence support the role of GABAergic dysfunction in neuro-developmental disorders. This review presents the molecules and mechanisms that underlie GABA system dysfunction in several neuro-d...

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Detalles Bibliográficos
Autor principal: Smith-Hicks, Constance L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867664/
https://www.ncbi.nlm.nih.gov/pubmed/24391546
http://dx.doi.org/10.3389/fncel.2013.00269
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author Smith-Hicks, Constance L.
author_facet Smith-Hicks, Constance L.
author_sort Smith-Hicks, Constance L.
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description The GABAergic system is central to the development and functional maturation of the nervous system. Emerging evidence support the role of GABAergic dysfunction in neuro-developmental disorders. This review presents the molecules and mechanisms that underlie GABA system dysfunction in several neuro-developmental disorders presenting in childhood. The impact on synaptic plasticity, neuronal circuit function and behavior, followed by targeted treatment strategies are discussed.
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spelling pubmed-38676642014-01-03 GABAergic dysfunction in pediatric neuro-developmental disorders Smith-Hicks, Constance L. Front Cell Neurosci Neuroscience The GABAergic system is central to the development and functional maturation of the nervous system. Emerging evidence support the role of GABAergic dysfunction in neuro-developmental disorders. This review presents the molecules and mechanisms that underlie GABA system dysfunction in several neuro-developmental disorders presenting in childhood. The impact on synaptic plasticity, neuronal circuit function and behavior, followed by targeted treatment strategies are discussed. Frontiers Media S.A. 2013-12-19 /pmc/articles/PMC3867664/ /pubmed/24391546 http://dx.doi.org/10.3389/fncel.2013.00269 Text en Copyright © 2013 Smith-Hicks. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Smith-Hicks, Constance L.
GABAergic dysfunction in pediatric neuro-developmental disorders
title GABAergic dysfunction in pediatric neuro-developmental disorders
title_full GABAergic dysfunction in pediatric neuro-developmental disorders
title_fullStr GABAergic dysfunction in pediatric neuro-developmental disorders
title_full_unstemmed GABAergic dysfunction in pediatric neuro-developmental disorders
title_short GABAergic dysfunction in pediatric neuro-developmental disorders
title_sort gabaergic dysfunction in pediatric neuro-developmental disorders
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867664/
https://www.ncbi.nlm.nih.gov/pubmed/24391546
http://dx.doi.org/10.3389/fncel.2013.00269
work_keys_str_mv AT smithhicksconstancel gabaergicdysfunctioninpediatricneurodevelopmentaldisorders

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