The 5-HT(3A) receptor is essential for fear extinction

The 5-HT(3) receptor, the only ionotropic 5-HT receptor, is expressed in limbic regions, including the hippocampus, amygdala, and cortex. However, it is not known whether it has a role in fear memory processes. Analysis of 5-HT(3A) receptor knockout mice in fear conditioning paradigms revealed that...

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Detalles Bibliográficos
Autores principales: Kondo, Makoto, Nakamura, Yukiko, Ishida, Yusuke, Yamada, Takahiro, Shimada, Shoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867712/
https://www.ncbi.nlm.nih.gov/pubmed/24344177
http://dx.doi.org/10.1101/lm.032193.113
Descripción
Sumario:The 5-HT(3) receptor, the only ionotropic 5-HT receptor, is expressed in limbic regions, including the hippocampus, amygdala, and cortex. However, it is not known whether it has a role in fear memory processes. Analysis of 5-HT(3A) receptor knockout mice in fear conditioning paradigms revealed that the 5-HT(3A) receptor is not required for the acquisition or retention of fear memory but is essential for the extinction of contextual and tone-cued fear. Our data suggest that the 5-HT(3A) receptor could be a key molecule regulating fear memory processes and a potential therapeutic target for fear disorders.

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