The 5-HT(3A) receptor is essential for fear extinction

The 5-HT(3) receptor, the only ionotropic 5-HT receptor, is expressed in limbic regions, including the hippocampus, amygdala, and cortex. However, it is not known whether it has a role in fear memory processes. Analysis of 5-HT(3A) receptor knockout mice in fear conditioning paradigms revealed that...

Descripción completa

Detalles Bibliográficos
Autores principales: Kondo, Makoto, Nakamura, Yukiko, Ishida, Yusuke, Yamada, Takahiro, Shimada, Shoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867712/
https://www.ncbi.nlm.nih.gov/pubmed/24344177
http://dx.doi.org/10.1101/lm.032193.113
_version_ 1782296347226931200
author Kondo, Makoto
Nakamura, Yukiko
Ishida, Yusuke
Yamada, Takahiro
Shimada, Shoichi
author_facet Kondo, Makoto
Nakamura, Yukiko
Ishida, Yusuke
Yamada, Takahiro
Shimada, Shoichi
author_sort Kondo, Makoto
collection PubMed
description The 5-HT(3) receptor, the only ionotropic 5-HT receptor, is expressed in limbic regions, including the hippocampus, amygdala, and cortex. However, it is not known whether it has a role in fear memory processes. Analysis of 5-HT(3A) receptor knockout mice in fear conditioning paradigms revealed that the 5-HT(3A) receptor is not required for the acquisition or retention of fear memory but is essential for the extinction of contextual and tone-cued fear. Our data suggest that the 5-HT(3A) receptor could be a key molecule regulating fear memory processes and a potential therapeutic target for fear disorders.
format Online
Article
Text
id pubmed-3867712
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Cold Spring Harbor Laboratory Press
record_format MEDLINE/PubMed
spelling pubmed-38677122015-01-01 The 5-HT(3A) receptor is essential for fear extinction Kondo, Makoto Nakamura, Yukiko Ishida, Yusuke Yamada, Takahiro Shimada, Shoichi Learn Mem Brief Communication The 5-HT(3) receptor, the only ionotropic 5-HT receptor, is expressed in limbic regions, including the hippocampus, amygdala, and cortex. However, it is not known whether it has a role in fear memory processes. Analysis of 5-HT(3A) receptor knockout mice in fear conditioning paradigms revealed that the 5-HT(3A) receptor is not required for the acquisition or retention of fear memory but is essential for the extinction of contextual and tone-cued fear. Our data suggest that the 5-HT(3A) receptor could be a key molecule regulating fear memory processes and a potential therapeutic target for fear disorders. Cold Spring Harbor Laboratory Press 2014-01 /pmc/articles/PMC3867712/ /pubmed/24344177 http://dx.doi.org/10.1101/lm.032193.113 Text en © 2013 Kondo et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.
spellingShingle Brief Communication
Kondo, Makoto
Nakamura, Yukiko
Ishida, Yusuke
Yamada, Takahiro
Shimada, Shoichi
The 5-HT(3A) receptor is essential for fear extinction
title The 5-HT(3A) receptor is essential for fear extinction
title_full The 5-HT(3A) receptor is essential for fear extinction
title_fullStr The 5-HT(3A) receptor is essential for fear extinction
title_full_unstemmed The 5-HT(3A) receptor is essential for fear extinction
title_short The 5-HT(3A) receptor is essential for fear extinction
title_sort 5-ht(3a) receptor is essential for fear extinction
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867712/
https://www.ncbi.nlm.nih.gov/pubmed/24344177
http://dx.doi.org/10.1101/lm.032193.113
work_keys_str_mv AT kondomakoto the5ht3areceptorisessentialforfearextinction
AT nakamurayukiko the5ht3areceptorisessentialforfearextinction
AT ishidayusuke the5ht3areceptorisessentialforfearextinction
AT yamadatakahiro the5ht3areceptorisessentialforfearextinction
AT shimadashoichi the5ht3areceptorisessentialforfearextinction
AT kondomakoto 5ht3areceptorisessentialforfearextinction
AT nakamurayukiko 5ht3areceptorisessentialforfearextinction
AT ishidayusuke 5ht3areceptorisessentialforfearextinction
AT yamadatakahiro 5ht3areceptorisessentialforfearextinction
AT shimadashoichi 5ht3areceptorisessentialforfearextinction

Ejemplares similares