Oral contrast enhances the resolution of in-life NIS reporter gene imaging

NIS reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that...

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Autores principales: Suksanpaisan, Lukkana, Pham, Linh, McIvor, Scott, Russell, Stephen J, Peng, Kah-Whye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867790/
https://www.ncbi.nlm.nih.gov/pubmed/24030210
http://dx.doi.org/10.1038/cgt.2013.57
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author Suksanpaisan, Lukkana
Pham, Linh
McIvor, Scott
Russell, Stephen J
Peng, Kah-Whye
author_facet Suksanpaisan, Lukkana
Pham, Linh
McIvor, Scott
Russell, Stephen J
Peng, Kah-Whye
author_sort Suksanpaisan, Lukkana
collection PubMed
description NIS reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that orally administered barium sulfate enhances CT definition of the stomach, masks background gamma ray emissions from the stomach, and enhances signal detection from radiotracer uptake in NIS-transduced organs.
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spelling pubmed-38677902014-05-01 Oral contrast enhances the resolution of in-life NIS reporter gene imaging Suksanpaisan, Lukkana Pham, Linh McIvor, Scott Russell, Stephen J Peng, Kah-Whye Cancer Gene Ther Article NIS reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that orally administered barium sulfate enhances CT definition of the stomach, masks background gamma ray emissions from the stomach, and enhances signal detection from radiotracer uptake in NIS-transduced organs. 2013-09-13 2013-11 /pmc/articles/PMC3867790/ /pubmed/24030210 http://dx.doi.org/10.1038/cgt.2013.57 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Suksanpaisan, Lukkana
Pham, Linh
McIvor, Scott
Russell, Stephen J
Peng, Kah-Whye
Oral contrast enhances the resolution of in-life NIS reporter gene imaging
title Oral contrast enhances the resolution of in-life NIS reporter gene imaging
title_full Oral contrast enhances the resolution of in-life NIS reporter gene imaging
title_fullStr Oral contrast enhances the resolution of in-life NIS reporter gene imaging
title_full_unstemmed Oral contrast enhances the resolution of in-life NIS reporter gene imaging
title_short Oral contrast enhances the resolution of in-life NIS reporter gene imaging
title_sort oral contrast enhances the resolution of in-life nis reporter gene imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867790/
https://www.ncbi.nlm.nih.gov/pubmed/24030210
http://dx.doi.org/10.1038/cgt.2013.57
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