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Nano Polymeric Carrier Fabrication Technologies for Advanced Antitumor Therapy
Comparing with the traditional therapeutic methods, newly developed cancer therapy based on the nanoparticulates attracted extensively interest due to its unique advantages. However, there are still some drawbacks such as the unfavorable in vivo performance for nanomedicine and undesirable tumor esc...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867855/ https://www.ncbi.nlm.nih.gov/pubmed/24369011 http://dx.doi.org/10.1155/2013/305089 |
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author | Li, Wei Zhao, Mengxin Ke, Changhong Zhang, Ge Zhang, Li Li, Huafei Zhang, Fulei Sun, Yun Dai, Jianxin Wang, Hao Guo, Yajun |
author_facet | Li, Wei Zhao, Mengxin Ke, Changhong Zhang, Ge Zhang, Li Li, Huafei Zhang, Fulei Sun, Yun Dai, Jianxin Wang, Hao Guo, Yajun |
author_sort | Li, Wei |
collection | PubMed |
description | Comparing with the traditional therapeutic methods, newly developed cancer therapy based on the nanoparticulates attracted extensively interest due to its unique advantages. However, there are still some drawbacks such as the unfavorable in vivo performance for nanomedicine and undesirable tumor escape from the immunotherapy. While as we know that the in vivo performance strongly depended on the nanocarrier structural properties, thus, the big gap between in vitro and in vivo can be overcome by nanocarrier's structural tailoring by fine chemical design and microstructural tuning. In addition, this fine nanocarrier's engineering can also provide practical solution to solve the problems in traditional cancer immunotherapy. In this paper, we review the latest development in nanomedicine, cancer therapy, and nanoimmunotherapy. We then give an explanation why fine nanocanrrie's engineering with special focus on the unique pathology of tumor microenvironments and properties of immunocells can obviously promote the in vivo performance and improve the therapeutic index of nanoimmunotherapy. |
format | Online Article Text |
id | pubmed-3867855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38678552013-12-24 Nano Polymeric Carrier Fabrication Technologies for Advanced Antitumor Therapy Li, Wei Zhao, Mengxin Ke, Changhong Zhang, Ge Zhang, Li Li, Huafei Zhang, Fulei Sun, Yun Dai, Jianxin Wang, Hao Guo, Yajun Biomed Res Int Review Article Comparing with the traditional therapeutic methods, newly developed cancer therapy based on the nanoparticulates attracted extensively interest due to its unique advantages. However, there are still some drawbacks such as the unfavorable in vivo performance for nanomedicine and undesirable tumor escape from the immunotherapy. While as we know that the in vivo performance strongly depended on the nanocarrier structural properties, thus, the big gap between in vitro and in vivo can be overcome by nanocarrier's structural tailoring by fine chemical design and microstructural tuning. In addition, this fine nanocarrier's engineering can also provide practical solution to solve the problems in traditional cancer immunotherapy. In this paper, we review the latest development in nanomedicine, cancer therapy, and nanoimmunotherapy. We then give an explanation why fine nanocanrrie's engineering with special focus on the unique pathology of tumor microenvironments and properties of immunocells can obviously promote the in vivo performance and improve the therapeutic index of nanoimmunotherapy. Hindawi Publishing Corporation 2013 2013-12-04 /pmc/articles/PMC3867855/ /pubmed/24369011 http://dx.doi.org/10.1155/2013/305089 Text en Copyright © 2013 Wei Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Li, Wei Zhao, Mengxin Ke, Changhong Zhang, Ge Zhang, Li Li, Huafei Zhang, Fulei Sun, Yun Dai, Jianxin Wang, Hao Guo, Yajun Nano Polymeric Carrier Fabrication Technologies for Advanced Antitumor Therapy |
title | Nano Polymeric Carrier Fabrication Technologies for Advanced Antitumor Therapy |
title_full | Nano Polymeric Carrier Fabrication Technologies for Advanced Antitumor Therapy |
title_fullStr | Nano Polymeric Carrier Fabrication Technologies for Advanced Antitumor Therapy |
title_full_unstemmed | Nano Polymeric Carrier Fabrication Technologies for Advanced Antitumor Therapy |
title_short | Nano Polymeric Carrier Fabrication Technologies for Advanced Antitumor Therapy |
title_sort | nano polymeric carrier fabrication technologies for advanced antitumor therapy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867855/ https://www.ncbi.nlm.nih.gov/pubmed/24369011 http://dx.doi.org/10.1155/2013/305089 |
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