Cargando…

Vascularized Bone Tissue Formation Induced by Fiber-Reinforced Scaffolds Cultured with Osteoblasts and Endothelial Cells

The repair of the damaged bone tissue caused by damage or bone disease was still a problem. Current strategies including the use of autografts and allografts have the disadvantages, namely, diseases transmission, tissue availability and donor morbidity. Bone tissue engineering has been developed and...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xinhui, Zhang, Guoping, Hou, Chuanyong, Wang, Hua, Yang, Yelin, Guan, Guoping, Dong, Wei, Gao, Hongyang, Feng, Qingling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867896/
https://www.ncbi.nlm.nih.gov/pubmed/24369019
http://dx.doi.org/10.1155/2013/854917
_version_ 1782296378682114048
author Liu, Xinhui
Zhang, Guoping
Hou, Chuanyong
Wang, Hua
Yang, Yelin
Guan, Guoping
Dong, Wei
Gao, Hongyang
Feng, Qingling
author_facet Liu, Xinhui
Zhang, Guoping
Hou, Chuanyong
Wang, Hua
Yang, Yelin
Guan, Guoping
Dong, Wei
Gao, Hongyang
Feng, Qingling
author_sort Liu, Xinhui
collection PubMed
description The repair of the damaged bone tissue caused by damage or bone disease was still a problem. Current strategies including the use of autografts and allografts have the disadvantages, namely, diseases transmission, tissue availability and donor morbidity. Bone tissue engineering has been developed and regarded as a new way of regenerating bone tissues to repair or substitute damaged or diseased ones. The main limitation in engineering in vitro tissues is the lack of a sufficient blood vessel system, the vascularization. In this paper, a new-typed hydroxyapatite/collagen composite scaffold which was reinforced by chitosan fibers and cultured with osteoblasts and endothelial cells was fabricated. General observation, histological observation, detection of the degree of vascularization, and X-ray examination had been done to learn the effect of vascularized bone repair materials on the regeneration of bone. The results show that new vessel and bone formed using implant cultured with osteoblasts and endothelial cells. Nanofiber-reinforced scaffold cultured with osteoblasts and endothelial cells can induce vascularized bone tissue formation.
format Online
Article
Text
id pubmed-3867896
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-38678962013-12-24 Vascularized Bone Tissue Formation Induced by Fiber-Reinforced Scaffolds Cultured with Osteoblasts and Endothelial Cells Liu, Xinhui Zhang, Guoping Hou, Chuanyong Wang, Hua Yang, Yelin Guan, Guoping Dong, Wei Gao, Hongyang Feng, Qingling Biomed Res Int Research Article The repair of the damaged bone tissue caused by damage or bone disease was still a problem. Current strategies including the use of autografts and allografts have the disadvantages, namely, diseases transmission, tissue availability and donor morbidity. Bone tissue engineering has been developed and regarded as a new way of regenerating bone tissues to repair or substitute damaged or diseased ones. The main limitation in engineering in vitro tissues is the lack of a sufficient blood vessel system, the vascularization. In this paper, a new-typed hydroxyapatite/collagen composite scaffold which was reinforced by chitosan fibers and cultured with osteoblasts and endothelial cells was fabricated. General observation, histological observation, detection of the degree of vascularization, and X-ray examination had been done to learn the effect of vascularized bone repair materials on the regeneration of bone. The results show that new vessel and bone formed using implant cultured with osteoblasts and endothelial cells. Nanofiber-reinforced scaffold cultured with osteoblasts and endothelial cells can induce vascularized bone tissue formation. Hindawi Publishing Corporation 2013 2013-12-04 /pmc/articles/PMC3867896/ /pubmed/24369019 http://dx.doi.org/10.1155/2013/854917 Text en Copyright © 2013 Xinhui Liu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Xinhui
Zhang, Guoping
Hou, Chuanyong
Wang, Hua
Yang, Yelin
Guan, Guoping
Dong, Wei
Gao, Hongyang
Feng, Qingling
Vascularized Bone Tissue Formation Induced by Fiber-Reinforced Scaffolds Cultured with Osteoblasts and Endothelial Cells
title Vascularized Bone Tissue Formation Induced by Fiber-Reinforced Scaffolds Cultured with Osteoblasts and Endothelial Cells
title_full Vascularized Bone Tissue Formation Induced by Fiber-Reinforced Scaffolds Cultured with Osteoblasts and Endothelial Cells
title_fullStr Vascularized Bone Tissue Formation Induced by Fiber-Reinforced Scaffolds Cultured with Osteoblasts and Endothelial Cells
title_full_unstemmed Vascularized Bone Tissue Formation Induced by Fiber-Reinforced Scaffolds Cultured with Osteoblasts and Endothelial Cells
title_short Vascularized Bone Tissue Formation Induced by Fiber-Reinforced Scaffolds Cultured with Osteoblasts and Endothelial Cells
title_sort vascularized bone tissue formation induced by fiber-reinforced scaffolds cultured with osteoblasts and endothelial cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867896/
https://www.ncbi.nlm.nih.gov/pubmed/24369019
http://dx.doi.org/10.1155/2013/854917
work_keys_str_mv AT liuxinhui vascularizedbonetissueformationinducedbyfiberreinforcedscaffoldsculturedwithosteoblastsandendothelialcells
AT zhangguoping vascularizedbonetissueformationinducedbyfiberreinforcedscaffoldsculturedwithosteoblastsandendothelialcells
AT houchuanyong vascularizedbonetissueformationinducedbyfiberreinforcedscaffoldsculturedwithosteoblastsandendothelialcells
AT wanghua vascularizedbonetissueformationinducedbyfiberreinforcedscaffoldsculturedwithosteoblastsandendothelialcells
AT yangyelin vascularizedbonetissueformationinducedbyfiberreinforcedscaffoldsculturedwithosteoblastsandendothelialcells
AT guanguoping vascularizedbonetissueformationinducedbyfiberreinforcedscaffoldsculturedwithosteoblastsandendothelialcells
AT dongwei vascularizedbonetissueformationinducedbyfiberreinforcedscaffoldsculturedwithosteoblastsandendothelialcells
AT gaohongyang vascularizedbonetissueformationinducedbyfiberreinforcedscaffoldsculturedwithosteoblastsandendothelialcells
AT fengqingling vascularizedbonetissueformationinducedbyfiberreinforcedscaffoldsculturedwithosteoblastsandendothelialcells