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Glutathionylated Lipid Aldehydes Are Products of Adipocyte Oxidative Stress and Activators of Macrophage Inflammation

Obesity-induced insulin resistance has been linked to adipose tissue lipid aldehyde production and protein carbonylation. Trans-4-hydroxy-2-nonenal (4-HNE) is the most abundant lipid aldehyde in murine adipose tissue and is metabolized by glutathione S-transferase A4 (GSTA4), producing glutathionyl-...

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Detalles Bibliográficos
Autores principales:	Frohnert, Brigitte I., Long, Eric K., Hahn, Wendy S., Bernlohr, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868039/ https://www.ncbi.nlm.nih.gov/pubmed/24062247 http://dx.doi.org/10.2337/db13-0777

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