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Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes

Studies of brain structure in type 1 diabetes (T1D) describe widespread neuroanatomical differences related to exposure to glycemic dysregulation in adults and adolescents. In this study, we investigate the neuroanatomical correlates of dysglycemia in very young children with early-onset T1D. Struct...

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Autores principales: Marzelli, Matthew J., Mazaika, Paul K., Barnea-Goraly, Naama, Hershey, Tamara, Tsalikian, Eva, Tamborlane, William, Mauras, Nelly, White, Neil H., Buckingham, Bruce, Beck, Roy W., Ruedy, Katrina J., Kollman, Craig, Cheng, Peiyao, Reiss, Allan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868050/
https://www.ncbi.nlm.nih.gov/pubmed/24170697
http://dx.doi.org/10.2337/db13-0179
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author Marzelli, Matthew J.
Mazaika, Paul K.
Barnea-Goraly, Naama
Hershey, Tamara
Tsalikian, Eva
Tamborlane, William
Mauras, Nelly
White, Neil H.
Buckingham, Bruce
Beck, Roy W.
Ruedy, Katrina J.
Kollman, Craig
Cheng, Peiyao
Reiss, Allan L.
author_facet Marzelli, Matthew J.
Mazaika, Paul K.
Barnea-Goraly, Naama
Hershey, Tamara
Tsalikian, Eva
Tamborlane, William
Mauras, Nelly
White, Neil H.
Buckingham, Bruce
Beck, Roy W.
Ruedy, Katrina J.
Kollman, Craig
Cheng, Peiyao
Reiss, Allan L.
author_sort Marzelli, Matthew J.
collection PubMed
description Studies of brain structure in type 1 diabetes (T1D) describe widespread neuroanatomical differences related to exposure to glycemic dysregulation in adults and adolescents. In this study, we investigate the neuroanatomical correlates of dysglycemia in very young children with early-onset T1D. Structural magnetic resonance images of the brain were acquired in 142 children with T1D and 68 age-matched control subjects (mean age 7.0 ± 1.7 years) on six identical scanners. Whole-brain volumetric analyses were conducted using voxel-based morphometry to detect regional differences between groups and to investigate correlations between regional brain volumes and measures of glycemic exposure (including data from continuous glucose monitoring). Relative to control subjects, the T1D group displayed decreased gray matter volume (GMV) in bilateral occipital and cerebellar regions (P < 0.001) and increased GMV in the left inferior prefrontal, insula, and temporal pole regions (P = 0.002). Within the T1D group, hyperglycemic exposure was associated with decreased GMV in medial frontal and temporal-occipital regions and increased GMV in lateral prefrontal regions. Cognitive correlations of intelligence quotient to GMV were found in cerebellar-occipital regions and medial prefrontal cortex for control subjects, as expected, but not for the T1D group. Thus, early-onset T1D affects regions of the brain that are associated with typical cognitive development.
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spelling pubmed-38680502015-01-01 Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes Marzelli, Matthew J. Mazaika, Paul K. Barnea-Goraly, Naama Hershey, Tamara Tsalikian, Eva Tamborlane, William Mauras, Nelly White, Neil H. Buckingham, Bruce Beck, Roy W. Ruedy, Katrina J. Kollman, Craig Cheng, Peiyao Reiss, Allan L. Diabetes Genetics/Genomes/Proteomics/Metabolomics Studies of brain structure in type 1 diabetes (T1D) describe widespread neuroanatomical differences related to exposure to glycemic dysregulation in adults and adolescents. In this study, we investigate the neuroanatomical correlates of dysglycemia in very young children with early-onset T1D. Structural magnetic resonance images of the brain were acquired in 142 children with T1D and 68 age-matched control subjects (mean age 7.0 ± 1.7 years) on six identical scanners. Whole-brain volumetric analyses were conducted using voxel-based morphometry to detect regional differences between groups and to investigate correlations between regional brain volumes and measures of glycemic exposure (including data from continuous glucose monitoring). Relative to control subjects, the T1D group displayed decreased gray matter volume (GMV) in bilateral occipital and cerebellar regions (P < 0.001) and increased GMV in the left inferior prefrontal, insula, and temporal pole regions (P = 0.002). Within the T1D group, hyperglycemic exposure was associated with decreased GMV in medial frontal and temporal-occipital regions and increased GMV in lateral prefrontal regions. Cognitive correlations of intelligence quotient to GMV were found in cerebellar-occipital regions and medial prefrontal cortex for control subjects, as expected, but not for the T1D group. Thus, early-onset T1D affects regions of the brain that are associated with typical cognitive development. American Diabetes Association 2014-01 2013-12-13 /pmc/articles/PMC3868050/ /pubmed/24170697 http://dx.doi.org/10.2337/db13-0179 Text en © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Genetics/Genomes/Proteomics/Metabolomics
Marzelli, Matthew J.
Mazaika, Paul K.
Barnea-Goraly, Naama
Hershey, Tamara
Tsalikian, Eva
Tamborlane, William
Mauras, Nelly
White, Neil H.
Buckingham, Bruce
Beck, Roy W.
Ruedy, Katrina J.
Kollman, Craig
Cheng, Peiyao
Reiss, Allan L.
Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes
title Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes
title_full Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes
title_fullStr Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes
title_full_unstemmed Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes
title_short Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes
title_sort neuroanatomical correlates of dysglycemia in young children with type 1 diabetes
topic Genetics/Genomes/Proteomics/Metabolomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868050/
https://www.ncbi.nlm.nih.gov/pubmed/24170697
http://dx.doi.org/10.2337/db13-0179
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