Carboxyl-Ester Lipase Maturity-Onset Diabetes of the Young Is Associated With Development of Pancreatic Cysts and Upregulated MAPK Signaling in Secretin-Stimulated Duodenal Fluid

Carboxyl-ester lipase (CEL) maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes and pancreatic exocrine dysfunction due to mutations in the CEL gene encoding CEL. The pathogenic mechanism for diabetes development is unknown. Since CEL is expressed mainly in pancreatic acinar...

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Detalles Bibliográficos
Autores principales: Ræder, Helge, McAllister, Fiona E., Tjora, Erling, Bhatt, Shweta, Haldorsen, Ingfrid, Hu, Jiang, Willems, Stefan M., Vesterhus, Mette, El Ouaamari, Abdelfattah, Liu, Manway, Ræder, Maria B., Immervoll, Heike, Hoem, Dag, Dimcevski, Georg, Njølstad, Pål R., Molven, Anders, Gygi, Steven P., Kulkarni, Rohit N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Pathophysiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868055/
https://www.ncbi.nlm.nih.gov/pubmed/24062244
http://dx.doi.org/10.2337/db13-1012

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