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Comparison of diabetes patients with “demyelinating” diabetic sensorimotor polyneuropathy to those diagnosed with CIDP

BACKGROUND: We have previously identified a subset of diabetic sensorimotor polyneuropathy (DSP) patients with probable demyelination related to poor glycemic control. We aimed to determine whether the clinical characteristics and electrodiagnostic classification of nerve injury in diabetes patients...

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Autores principales: Dunnigan, Samantha K, Ebadi, Hamid, Breiner, Ari, Katzberg, Hans D, Lovblom, Leif E, Perkins, Bruce A, Bril, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Inc 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868171/
https://www.ncbi.nlm.nih.gov/pubmed/24363969
http://dx.doi.org/10.1002/brb3.177
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author Dunnigan, Samantha K
Ebadi, Hamid
Breiner, Ari
Katzberg, Hans D
Lovblom, Leif E
Perkins, Bruce A
Bril, Vera
author_facet Dunnigan, Samantha K
Ebadi, Hamid
Breiner, Ari
Katzberg, Hans D
Lovblom, Leif E
Perkins, Bruce A
Bril, Vera
author_sort Dunnigan, Samantha K
collection PubMed
description BACKGROUND: We have previously identified a subset of diabetic sensorimotor polyneuropathy (DSP) patients with probable demyelination related to poor glycemic control. We aimed to determine whether the clinical characteristics and electrodiagnostic classification of nerve injury in diabetes patients with “demyelinating” DSP (D-DSP) differed from those diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP) (CIDP + diabetes mellitus [DM]). METHODS: D-DSP (56) and CIDP + DM (67) subjects underwent clinical examination and nerve conduction studies (NCS), and were compared using analysis of variance, contingency tables, and Kruskal–Wallis analyses. RESULTS: Of the 123 subjects with a mean age of 60.5 ± 15.6 years and mean hemoglobin A(1c) (HbA(1c)) of 8.2 ± 2.2%, 54% had CIDP + DM and 46% had D-DSP. CIDP + DM subjects were older (P = 0.0003), had shorter duration of diabetes (P = 0.005), and more severe neuropathy as indicated by Toronto Clinical Neuropathy Score (TCNS) (P = 0.003), deep tendon reflexes (P = 0.02), and vibration perception thresholds (VPT) (P = 0.01, P = 0.02). The mean HbA(1c) value for D-DSP subjects (8.9 ± 2.3%) was higher than in CIDP + DM subjects (7.7 ± 2.0%, P = 0.02). CONCLUSIONS: The clinical phenotype and electrophysiological profile of CIDP + DM patients is marked by more severe neuropathy and better glycemic control than in patients with D-DSP. These findings indicate that these two conditions – despite similarities in their electrophysiological pattern of demyelination – likely differ in etiology.
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spelling pubmed-38681712013-12-20 Comparison of diabetes patients with “demyelinating” diabetic sensorimotor polyneuropathy to those diagnosed with CIDP Dunnigan, Samantha K Ebadi, Hamid Breiner, Ari Katzberg, Hans D Lovblom, Leif E Perkins, Bruce A Bril, Vera Brain Behav Original Research BACKGROUND: We have previously identified a subset of diabetic sensorimotor polyneuropathy (DSP) patients with probable demyelination related to poor glycemic control. We aimed to determine whether the clinical characteristics and electrodiagnostic classification of nerve injury in diabetes patients with “demyelinating” DSP (D-DSP) differed from those diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP) (CIDP + diabetes mellitus [DM]). METHODS: D-DSP (56) and CIDP + DM (67) subjects underwent clinical examination and nerve conduction studies (NCS), and were compared using analysis of variance, contingency tables, and Kruskal–Wallis analyses. RESULTS: Of the 123 subjects with a mean age of 60.5 ± 15.6 years and mean hemoglobin A(1c) (HbA(1c)) of 8.2 ± 2.2%, 54% had CIDP + DM and 46% had D-DSP. CIDP + DM subjects were older (P = 0.0003), had shorter duration of diabetes (P = 0.005), and more severe neuropathy as indicated by Toronto Clinical Neuropathy Score (TCNS) (P = 0.003), deep tendon reflexes (P = 0.02), and vibration perception thresholds (VPT) (P = 0.01, P = 0.02). The mean HbA(1c) value for D-DSP subjects (8.9 ± 2.3%) was higher than in CIDP + DM subjects (7.7 ± 2.0%, P = 0.02). CONCLUSIONS: The clinical phenotype and electrophysiological profile of CIDP + DM patients is marked by more severe neuropathy and better glycemic control than in patients with D-DSP. These findings indicate that these two conditions – despite similarities in their electrophysiological pattern of demyelination – likely differ in etiology. Blackwell Publishing Inc 2013-11 2013-09-22 /pmc/articles/PMC3868171/ /pubmed/24363969 http://dx.doi.org/10.1002/brb3.177 Text en © 2013 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Original Research
Dunnigan, Samantha K
Ebadi, Hamid
Breiner, Ari
Katzberg, Hans D
Lovblom, Leif E
Perkins, Bruce A
Bril, Vera
Comparison of diabetes patients with “demyelinating” diabetic sensorimotor polyneuropathy to those diagnosed with CIDP
title Comparison of diabetes patients with “demyelinating” diabetic sensorimotor polyneuropathy to those diagnosed with CIDP
title_full Comparison of diabetes patients with “demyelinating” diabetic sensorimotor polyneuropathy to those diagnosed with CIDP
title_fullStr Comparison of diabetes patients with “demyelinating” diabetic sensorimotor polyneuropathy to those diagnosed with CIDP
title_full_unstemmed Comparison of diabetes patients with “demyelinating” diabetic sensorimotor polyneuropathy to those diagnosed with CIDP
title_short Comparison of diabetes patients with “demyelinating” diabetic sensorimotor polyneuropathy to those diagnosed with CIDP
title_sort comparison of diabetes patients with “demyelinating” diabetic sensorimotor polyneuropathy to those diagnosed with cidp
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868171/
https://www.ncbi.nlm.nih.gov/pubmed/24363969
http://dx.doi.org/10.1002/brb3.177
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