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Widespread sex differences in gene expression and splicing in the adult human brain
There is strong evidence to show that men and women differ in terms of neurodevelopment, neurochemistry and susceptibility to neurodegenerative and neuropsychiatric disease. The molecular basis of these differences remains unclear. Progress in this field has been hampered by the lack of genome-wide...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868224/ https://www.ncbi.nlm.nih.gov/pubmed/24264146 http://dx.doi.org/10.1038/ncomms3771 |
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author | Trabzuni, Daniah Ramasamy, Adaikalavan Imran, Sabaena Walker, Robert Smith, Colin Weale, Michael E. Hardy, John Ryten, Mina |
author_facet | Trabzuni, Daniah Ramasamy, Adaikalavan Imran, Sabaena Walker, Robert Smith, Colin Weale, Michael E. Hardy, John Ryten, Mina |
author_sort | Trabzuni, Daniah |
collection | PubMed |
description | There is strong evidence to show that men and women differ in terms of neurodevelopment, neurochemistry and susceptibility to neurodegenerative and neuropsychiatric disease. The molecular basis of these differences remains unclear. Progress in this field has been hampered by the lack of genome-wide information on sex differences in gene expression and in particular splicing in the human brain. Here we address this issue by using post-mortem adult human brain and spinal cord samples originating from 137 neuropathologically confirmed control individuals to study whole-genome gene expression and splicing in 12 CNS regions. We show that sex differences in gene expression and splicing are widespread in adult human brain, being detectable in all major brain regions and involving 2.5% of all expressed genes. We give examples of genes where sex-biased expression is both disease-relevant and likely to have functional consequences, and provide evidence suggesting that sex biases in expression may reflect sex-biased gene regulatory structures. |
format | Online Article Text |
id | pubmed-3868224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Pub. Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-38682242013-12-20 Widespread sex differences in gene expression and splicing in the adult human brain Trabzuni, Daniah Ramasamy, Adaikalavan Imran, Sabaena Walker, Robert Smith, Colin Weale, Michael E. Hardy, John Ryten, Mina Nat Commun Article There is strong evidence to show that men and women differ in terms of neurodevelopment, neurochemistry and susceptibility to neurodegenerative and neuropsychiatric disease. The molecular basis of these differences remains unclear. Progress in this field has been hampered by the lack of genome-wide information on sex differences in gene expression and in particular splicing in the human brain. Here we address this issue by using post-mortem adult human brain and spinal cord samples originating from 137 neuropathologically confirmed control individuals to study whole-genome gene expression and splicing in 12 CNS regions. We show that sex differences in gene expression and splicing are widespread in adult human brain, being detectable in all major brain regions and involving 2.5% of all expressed genes. We give examples of genes where sex-biased expression is both disease-relevant and likely to have functional consequences, and provide evidence suggesting that sex biases in expression may reflect sex-biased gene regulatory structures. Nature Pub. Group 2013-11-22 /pmc/articles/PMC3868224/ /pubmed/24264146 http://dx.doi.org/10.1038/ncomms3771 Text en Copyright © 2013, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Article Trabzuni, Daniah Ramasamy, Adaikalavan Imran, Sabaena Walker, Robert Smith, Colin Weale, Michael E. Hardy, John Ryten, Mina Widespread sex differences in gene expression and splicing in the adult human brain |
title | Widespread sex differences in gene expression and splicing in the adult human brain |
title_full | Widespread sex differences in gene expression and splicing in the adult human brain |
title_fullStr | Widespread sex differences in gene expression and splicing in the adult human brain |
title_full_unstemmed | Widespread sex differences in gene expression and splicing in the adult human brain |
title_short | Widespread sex differences in gene expression and splicing in the adult human brain |
title_sort | widespread sex differences in gene expression and splicing in the adult human brain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868224/ https://www.ncbi.nlm.nih.gov/pubmed/24264146 http://dx.doi.org/10.1038/ncomms3771 |
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