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Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif

MicroRNAs modulate tumorigenesis through suppression of specific genes. As many tumour types rely on overlapping oncogenic pathways, a core set of microRNAs may exist, which consistently drives or suppresses tumorigenesis in many cancer types. Here we integrate The Cancer Genome Atlas (TCGA) pan-can...

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Autores principales: Hamilton, Mark P., Rajapakshe, Kimal, Hartig, Sean M., Reva, Boris, McLellan, Michael D., Kandoth, Cyriac, Ding, Li, Zack, Travis I., Gunaratne, Preethi H., Wheeler, David A., Coarfa, Cristian, McGuire, Sean E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868236/
https://www.ncbi.nlm.nih.gov/pubmed/24220575
http://dx.doi.org/10.1038/ncomms3730
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author Hamilton, Mark P.
Rajapakshe, Kimal
Hartig, Sean M.
Reva, Boris
McLellan, Michael D.
Kandoth, Cyriac
Ding, Li
Zack, Travis I.
Gunaratne, Preethi H.
Wheeler, David A.
Coarfa, Cristian
McGuire, Sean E.
author_facet Hamilton, Mark P.
Rajapakshe, Kimal
Hartig, Sean M.
Reva, Boris
McLellan, Michael D.
Kandoth, Cyriac
Ding, Li
Zack, Travis I.
Gunaratne, Preethi H.
Wheeler, David A.
Coarfa, Cristian
McGuire, Sean E.
author_sort Hamilton, Mark P.
collection PubMed
description MicroRNAs modulate tumorigenesis through suppression of specific genes. As many tumour types rely on overlapping oncogenic pathways, a core set of microRNAs may exist, which consistently drives or suppresses tumorigenesis in many cancer types. Here we integrate The Cancer Genome Atlas (TCGA) pan-cancer data set with a microRNA target atlas composed of publicly available Argonaute Crosslinking Immunoprecipitation (AGO-CLIP) data to identify pan-tumour microRNA drivers of cancer. Through this analysis, we show a pan-cancer, coregulated oncogenic microRNA ‘superfamily’ consisting of the miR-17, miR-19, miR-130, miR-93, miR-18, miR-455 and miR-210 seed families, which cotargets critical tumour suppressors via a central GUGC core motif. We subsequently define mutations in microRNA target sites using the AGO-CLIP microRNA target atlas and TCGA exome-sequencing data. These combined analyses identify pan-cancer oncogenic cotargeting of the phosphoinositide 3-kinase, TGFβ and p53 pathways by the miR-17-19-130 superfamily members.
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spelling pubmed-38682362013-12-20 Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif Hamilton, Mark P. Rajapakshe, Kimal Hartig, Sean M. Reva, Boris McLellan, Michael D. Kandoth, Cyriac Ding, Li Zack, Travis I. Gunaratne, Preethi H. Wheeler, David A. Coarfa, Cristian McGuire, Sean E. Nat Commun Article MicroRNAs modulate tumorigenesis through suppression of specific genes. As many tumour types rely on overlapping oncogenic pathways, a core set of microRNAs may exist, which consistently drives or suppresses tumorigenesis in many cancer types. Here we integrate The Cancer Genome Atlas (TCGA) pan-cancer data set with a microRNA target atlas composed of publicly available Argonaute Crosslinking Immunoprecipitation (AGO-CLIP) data to identify pan-tumour microRNA drivers of cancer. Through this analysis, we show a pan-cancer, coregulated oncogenic microRNA ‘superfamily’ consisting of the miR-17, miR-19, miR-130, miR-93, miR-18, miR-455 and miR-210 seed families, which cotargets critical tumour suppressors via a central GUGC core motif. We subsequently define mutations in microRNA target sites using the AGO-CLIP microRNA target atlas and TCGA exome-sequencing data. These combined analyses identify pan-cancer oncogenic cotargeting of the phosphoinositide 3-kinase, TGFβ and p53 pathways by the miR-17-19-130 superfamily members. Nature Pub. Group 2013-11-13 /pmc/articles/PMC3868236/ /pubmed/24220575 http://dx.doi.org/10.1038/ncomms3730 Text en Copyright © 2013, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Article
Hamilton, Mark P.
Rajapakshe, Kimal
Hartig, Sean M.
Reva, Boris
McLellan, Michael D.
Kandoth, Cyriac
Ding, Li
Zack, Travis I.
Gunaratne, Preethi H.
Wheeler, David A.
Coarfa, Cristian
McGuire, Sean E.
Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif
title Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif
title_full Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif
title_fullStr Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif
title_full_unstemmed Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif
title_short Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif
title_sort identification of a pan-cancer oncogenic microrna superfamily anchored by a central core seed motif
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868236/
https://www.ncbi.nlm.nih.gov/pubmed/24220575
http://dx.doi.org/10.1038/ncomms3730
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