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Clinical consequences of human evolution shaped by cultural trends
Recent reports suggest that increased human population size, decreased negative selection pertaining to some phenotypes and associated genotypes and a possibly increased de novo mutation burden for newborns that relates to paternal age at conception are contributing to an expansion of human genetic...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Oxford University Press
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868389/ https://www.ncbi.nlm.nih.gov/pubmed/24481183 http://dx.doi.org/10.1093/emph/eos006 |
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author | Greenspan, Neil S. |
author_facet | Greenspan, Neil S. |
author_sort | Greenspan, Neil S. |
collection | PubMed |
description | Recent reports suggest that increased human population size, decreased negative selection pertaining to some phenotypes and associated genotypes and a possibly increased de novo mutation burden for newborns that relates to paternal age at conception are contributing to an expansion of human genetic diversity. Some of this diversity can be expected to contribute to disease. Because all of the preceding diversity-enhancing factors are to a significant degree consequences of cultural developments, it can be argued that the future clinical burden of the human population will be shaped in part by a human evolutionary trajectory substantially influenced by culturally mediated effects on the number of mutations in the gene pool and on the intensity of selection on some of the phenotypes associated with new genetic variants. |
format | Online Article Text |
id | pubmed-3868389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38683892014-01-06 Clinical consequences of human evolution shaped by cultural trends Greenspan, Neil S. Evol Med Public Health Commentary Recent reports suggest that increased human population size, decreased negative selection pertaining to some phenotypes and associated genotypes and a possibly increased de novo mutation burden for newborns that relates to paternal age at conception are contributing to an expansion of human genetic diversity. Some of this diversity can be expected to contribute to disease. Because all of the preceding diversity-enhancing factors are to a significant degree consequences of cultural developments, it can be argued that the future clinical burden of the human population will be shaped in part by a human evolutionary trajectory substantially influenced by culturally mediated effects on the number of mutations in the gene pool and on the intensity of selection on some of the phenotypes associated with new genetic variants. Oxford University Press 2013 2013-01-03 /pmc/articles/PMC3868389/ /pubmed/24481183 http://dx.doi.org/10.1093/emph/eos006 Text en © The Author(s) 2013. Published by Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health. http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Commentary Greenspan, Neil S. Clinical consequences of human evolution shaped by cultural trends |
title | Clinical consequences of human evolution shaped by cultural trends |
title_full | Clinical consequences of human evolution shaped by cultural trends |
title_fullStr | Clinical consequences of human evolution shaped by cultural trends |
title_full_unstemmed | Clinical consequences of human evolution shaped by cultural trends |
title_short | Clinical consequences of human evolution shaped by cultural trends |
title_sort | clinical consequences of human evolution shaped by cultural trends |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868389/ https://www.ncbi.nlm.nih.gov/pubmed/24481183 http://dx.doi.org/10.1093/emph/eos006 |
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