Utilizing a Dynamical Description of IspH to Aid in the Development of Novel Antimicrobial Drugs

The nonmevalonate pathway is responsible for isoprenoid production in microbes, including H. pylori, M. tuberculosis and P. falciparum, but is nonexistent in humans, thus providing a desirable route for antibacterial and antimalarial drug discovery. We coordinate a structural study of IspH, a [4Fe-4...

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Detalles Bibliográficos
Autores principales: Blachly, Patrick G., de Oliveira, César A. F., Williams, Sarah L., McCammon, J. Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868525/
https://www.ncbi.nlm.nih.gov/pubmed/24367248
http://dx.doi.org/10.1371/journal.pcbi.1003395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868525/
https://www.ncbi.nlm.nih.gov/pubmed/24367248
http://dx.doi.org/10.1371/journal.pcbi.1003395

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