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Utilizing a Dynamical Description of IspH to Aid in the Development of Novel Antimicrobial Drugs
The nonmevalonate pathway is responsible for isoprenoid production in microbes, including H. pylori, M. tuberculosis and P. falciparum, but is nonexistent in humans, thus providing a desirable route for antibacterial and antimalarial drug discovery. We coordinate a structural study of IspH, a [4Fe-4...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868525/ https://www.ncbi.nlm.nih.gov/pubmed/24367248 http://dx.doi.org/10.1371/journal.pcbi.1003395 |