A Disorder-Induced Domino-Like Destabilization Mechanism Governs the Folding and Functional Dynamics of the Repeat Protein IκBα

The stability of the repeat protein IκBα, a transcriptional inhibitor in mammalian cells, is critical in the functioning of the NF-κB signaling module implicated in an array of cellular processes, including cell growth, disease, immunity and apoptosis. Structurally, IκBα is complex, with both ordere...

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Detalles Bibliográficos
Autores principales: Sivanandan, Srinivasan, Naganathan, Athi N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868533/
https://www.ncbi.nlm.nih.gov/pubmed/24367251
http://dx.doi.org/10.1371/journal.pcbi.1003403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868533/
https://www.ncbi.nlm.nih.gov/pubmed/24367251
http://dx.doi.org/10.1371/journal.pcbi.1003403

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