Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain

The enhancer-of-zeste homolog 2 (EZH2) gene product is an 87 kDa polycomb group (PcG) protein containing a C-terminal methyltransferase SET domain. EZH2, along with binding partners, i.e., EED and SUZ12, upon which it is dependent for activity forms the core of the polycomb repressive complex 2 (PRC...

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Detalles Bibliográficos
Autores principales: Antonysamy, Stephen, Condon, Bradley, Druzina, Zhanna, Bonanno, Jeffrey B., Gheyi, Tarun, Zhang, Feiyu, MacEwan, Iain, Zhang, Aiping, Ashok, Sheela, Rodgers, Logan, Russell, Marijane, Gately Luz, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868555/
https://www.ncbi.nlm.nih.gov/pubmed/24367637
http://dx.doi.org/10.1371/journal.pone.0084147

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