OBATOCLAX and ABT-737 Induce ER Stress Responses in Human Melanoma Cells that Limit Induction of Apoptosis

Anti-apoptotic Bcl-2 family proteins, in particular, Mcl-1, are known to play a critical role in resistance of human melanoma cells to induction of apoptosis by endoplasmic reticulum stress and other agents. The present study examined whether the BH3 mimetics, Obatoclax and ABT-737, which inhibit mu...

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Detalles Bibliográficos
Autores principales: Wroblewski, David, Jiang, Chen Chen, Croft, Amanda, Farrelly, Margaret L., Zhang, Xu Dong, Hersey, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868604/
https://www.ncbi.nlm.nih.gov/pubmed/24367627
http://dx.doi.org/10.1371/journal.pone.0084073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868604/
https://www.ncbi.nlm.nih.gov/pubmed/24367627
http://dx.doi.org/10.1371/journal.pone.0084073

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