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Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the R6/1 Mouse Model of Huntington’s Disease

Huntington’s disease (HD) is caused by the expansion of a CAG repeat in the huntingtin (HTT) gene. The R6 mouse models of HD express a mutant version of exon 1 HTT and typically develop motor and cognitive impairments, a widespread huntingtin (HTT) aggregate pathology and brain atrophy. Unlike the m...

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Detalles Bibliográficos
Autores principales:	Rattray, Ivan, Smith, Edward J., Crum, William R., Walker, Thomas A., Gale, Richard, Bates, Gillian P., Modo, Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868608/ https://www.ncbi.nlm.nih.gov/pubmed/24367693 http://dx.doi.org/10.1371/journal.pone.0084726

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