SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK

Efficient coupling of cellular energy production to metabolic demand is crucial to maintain organismal homeostasis. Here, we report that the mitochondrial Sirtuin Sirt4 regulates mitochondrial ATP homeostasis. We find that Sirt4 affects mitochondrial uncoupling via the adenine nucleotide translocato...

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Detalles Bibliográficos
Autores principales: Ho, Linh, Titus, Allen Sam, Banerjee, Kushal Kr, George, Suji, Lin, Wei, Deota, Shaunak, Saha, Asish K., Nakamura, Ken, Gut, Philipp, Verdin, Eric, Kolthur-Seetharam, Ullas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868726/
https://www.ncbi.nlm.nih.gov/pubmed/24296486

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