Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy

African trypanosomes are capable of both de novo synthesis and salvage of pyrimidines. The last two steps in de novo synthesis are catalysed by UMP synthase (UMPS) – a bifunctional enzyme comprising orotate phosphoribosyl transferase (OPRT) and orotidine monophosphate decarboxylase (OMPDC). To inves...

Descripción completa

Detalles Bibliográficos
Autores principales: Ong, Han B, Sienkiewicz, Natasha, Wyllie, Susan, Patterson, Stephen, Fairlamb, Alan H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Ltd 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868941/
https://www.ncbi.nlm.nih.gov/pubmed/23980694
http://dx.doi.org/10.1111/mmi.12376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868941/
https://www.ncbi.nlm.nih.gov/pubmed/23980694
http://dx.doi.org/10.1111/mmi.12376

Ejemplares similares