Cargando…

Closing the loop of deep brain stimulation

High-frequency deep brain stimulation is used to treat a wide range of brain disorders, like Parkinson's disease. The stimulated networks usually share common electrophysiological signatures, including hyperactivity and/or dysrhythmia. From a clinical perspective, HFS is expected to alleviate c...

Descripción completa

Detalles Bibliográficos
Autores principales: Carron, Romain, Chaillet, Antoine, Filipchuk, Anton, Pasillas-Lépine, William, Hammond, Constance
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868949/
https://www.ncbi.nlm.nih.gov/pubmed/24391555
http://dx.doi.org/10.3389/fnsys.2013.00112
_version_ 1782296517001871360
author Carron, Romain
Chaillet, Antoine
Filipchuk, Anton
Pasillas-Lépine, William
Hammond, Constance
author_facet Carron, Romain
Chaillet, Antoine
Filipchuk, Anton
Pasillas-Lépine, William
Hammond, Constance
author_sort Carron, Romain
collection PubMed
description High-frequency deep brain stimulation is used to treat a wide range of brain disorders, like Parkinson's disease. The stimulated networks usually share common electrophysiological signatures, including hyperactivity and/or dysrhythmia. From a clinical perspective, HFS is expected to alleviate clinical signs without generating adverse effects. Here, we consider whether the classical open-loop HFS fulfills these criteria and outline current experimental or theoretical research on the different types of closed-loop DBS that could provide better clinical outcomes. In the first part of the review, the two routes followed by HFS-evoked axonal spikes are explored. In one direction, orthodromic spikes functionally de-afferent the stimulated nucleus from its downstream target networks. In the opposite direction, antidromic spikes prevent this nucleus from being influenced by its afferent networks. As a result, the pathological synchronized activity no longer propagates from the cortical networks to the stimulated nucleus. The overall result can be described as a reversible functional de-afferentation of the stimulated nucleus from its upstream and downstream nuclei. In the second part of the review, the latest advances in closed-loop DBS are considered. Some of the proposed approaches are based on mathematical models, which emphasize different aspects of the parkinsonian basal ganglia: excessive synchronization, abnormal firing-rate rhythms, and a deficient thalamo-cortical relay. The stimulation strategies are classified depending on the control-theory techniques on which they are based: adaptive and on-demand stimulation schemes, delayed and multi-site approaches, stimulations based on proportional and/or derivative control actions, optimal control strategies. Some of these strategies have been validated experimentally, but there is still a large reservoir of theoretical work that may point to ways of improving practical treatment.
format Online
Article
Text
id pubmed-3868949
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-38689492014-01-03 Closing the loop of deep brain stimulation Carron, Romain Chaillet, Antoine Filipchuk, Anton Pasillas-Lépine, William Hammond, Constance Front Syst Neurosci Neuroscience High-frequency deep brain stimulation is used to treat a wide range of brain disorders, like Parkinson's disease. The stimulated networks usually share common electrophysiological signatures, including hyperactivity and/or dysrhythmia. From a clinical perspective, HFS is expected to alleviate clinical signs without generating adverse effects. Here, we consider whether the classical open-loop HFS fulfills these criteria and outline current experimental or theoretical research on the different types of closed-loop DBS that could provide better clinical outcomes. In the first part of the review, the two routes followed by HFS-evoked axonal spikes are explored. In one direction, orthodromic spikes functionally de-afferent the stimulated nucleus from its downstream target networks. In the opposite direction, antidromic spikes prevent this nucleus from being influenced by its afferent networks. As a result, the pathological synchronized activity no longer propagates from the cortical networks to the stimulated nucleus. The overall result can be described as a reversible functional de-afferentation of the stimulated nucleus from its upstream and downstream nuclei. In the second part of the review, the latest advances in closed-loop DBS are considered. Some of the proposed approaches are based on mathematical models, which emphasize different aspects of the parkinsonian basal ganglia: excessive synchronization, abnormal firing-rate rhythms, and a deficient thalamo-cortical relay. The stimulation strategies are classified depending on the control-theory techniques on which they are based: adaptive and on-demand stimulation schemes, delayed and multi-site approaches, stimulations based on proportional and/or derivative control actions, optimal control strategies. Some of these strategies have been validated experimentally, but there is still a large reservoir of theoretical work that may point to ways of improving practical treatment. Frontiers Media S.A. 2013-12-20 /pmc/articles/PMC3868949/ /pubmed/24391555 http://dx.doi.org/10.3389/fnsys.2013.00112 Text en Copyright © 2013 Carron, Chaillet, Filipchuk, Pasillas-Lépine and Hammond. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Carron, Romain
Chaillet, Antoine
Filipchuk, Anton
Pasillas-Lépine, William
Hammond, Constance
Closing the loop of deep brain stimulation
title Closing the loop of deep brain stimulation
title_full Closing the loop of deep brain stimulation
title_fullStr Closing the loop of deep brain stimulation
title_full_unstemmed Closing the loop of deep brain stimulation
title_short Closing the loop of deep brain stimulation
title_sort closing the loop of deep brain stimulation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868949/
https://www.ncbi.nlm.nih.gov/pubmed/24391555
http://dx.doi.org/10.3389/fnsys.2013.00112
work_keys_str_mv AT carronromain closingtheloopofdeepbrainstimulation
AT chailletantoine closingtheloopofdeepbrainstimulation
AT filipchukanton closingtheloopofdeepbrainstimulation
AT pasillaslepinewilliam closingtheloopofdeepbrainstimulation
AT hammondconstance closingtheloopofdeepbrainstimulation