Microwave-assisted synthesis of 5,6-dihydroindolo[1,2-a]quinoxaline derivatives through copper-catalyzed intramolecular N-arylation

An efficient and practical protocol has been developed to synthesize 5,6-dihydroindolo[1,2-a]quinoxaline derivatives by CuI-catalyzed intramolecular N-arylation under microwave irradiation. This method rapidly afforded the tetracyclic products with good to excellent yields (83–97%) in short reaction...

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Detalles Bibliográficos
Autores principales: Zhao, Fei, Zhang, Lei, Liu, Hailong, Zhou, Shengbin, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869252/
https://www.ncbi.nlm.nih.gov/pubmed/24367414
http://dx.doi.org/10.3762/bjoc.9.285
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author Zhao, Fei
Zhang, Lei
Liu, Hailong
Zhou, Shengbin
Liu, Hong
author_facet Zhao, Fei
Zhang, Lei
Liu, Hailong
Zhou, Shengbin
Liu, Hong
author_sort Zhao, Fei
collection PubMed
description An efficient and practical protocol has been developed to synthesize 5,6-dihydroindolo[1,2-a]quinoxaline derivatives by CuI-catalyzed intramolecular N-arylation under microwave irradiation. This method rapidly afforded the tetracyclic products with good to excellent yields (83–97%) in short reaction times (45–60 min).
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spelling pubmed-38692522013-12-23 Microwave-assisted synthesis of 5,6-dihydroindolo[1,2-a]quinoxaline derivatives through copper-catalyzed intramolecular N-arylation Zhao, Fei Zhang, Lei Liu, Hailong Zhou, Shengbin Liu, Hong Beilstein J Org Chem Full Research Paper An efficient and practical protocol has been developed to synthesize 5,6-dihydroindolo[1,2-a]quinoxaline derivatives by CuI-catalyzed intramolecular N-arylation under microwave irradiation. This method rapidly afforded the tetracyclic products with good to excellent yields (83–97%) in short reaction times (45–60 min). Beilstein-Institut 2013-11-14 /pmc/articles/PMC3869252/ /pubmed/24367414 http://dx.doi.org/10.3762/bjoc.9.285 Text en Copyright © 2013, Zhao et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Zhao, Fei
Zhang, Lei
Liu, Hailong
Zhou, Shengbin
Liu, Hong
Microwave-assisted synthesis of 5,6-dihydroindolo[1,2-a]quinoxaline derivatives through copper-catalyzed intramolecular N-arylation
title Microwave-assisted synthesis of 5,6-dihydroindolo[1,2-a]quinoxaline derivatives through copper-catalyzed intramolecular N-arylation
title_full Microwave-assisted synthesis of 5,6-dihydroindolo[1,2-a]quinoxaline derivatives through copper-catalyzed intramolecular N-arylation
title_fullStr Microwave-assisted synthesis of 5,6-dihydroindolo[1,2-a]quinoxaline derivatives through copper-catalyzed intramolecular N-arylation
title_full_unstemmed Microwave-assisted synthesis of 5,6-dihydroindolo[1,2-a]quinoxaline derivatives through copper-catalyzed intramolecular N-arylation
title_short Microwave-assisted synthesis of 5,6-dihydroindolo[1,2-a]quinoxaline derivatives through copper-catalyzed intramolecular N-arylation
title_sort microwave-assisted synthesis of 5,6-dihydroindolo[1,2-a]quinoxaline derivatives through copper-catalyzed intramolecular n-arylation
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869252/
https://www.ncbi.nlm.nih.gov/pubmed/24367414
http://dx.doi.org/10.3762/bjoc.9.285
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