Cargando…
Biosynthesis of rare hexoses using microorganisms and related enzymes
Rare sugars, referred to as monosaccharides and their derivatives that rarely exist in nature, can be applied in many areas ranging from foodstuffs to pharmaceutical and nutrition industry, or as starting materials for various natural products and drug candidates. Unfortunately, an important factor...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869271/ https://www.ncbi.nlm.nih.gov/pubmed/24367410 http://dx.doi.org/10.3762/bjoc.9.281 |
_version_ | 1782296547809034240 |
---|---|
author | Li, Zijie Gao, Yahui Nakanishi, Hideki Gao, Xiaodong Cai, Li |
author_facet | Li, Zijie Gao, Yahui Nakanishi, Hideki Gao, Xiaodong Cai, Li |
author_sort | Li, Zijie |
collection | PubMed |
description | Rare sugars, referred to as monosaccharides and their derivatives that rarely exist in nature, can be applied in many areas ranging from foodstuffs to pharmaceutical and nutrition industry, or as starting materials for various natural products and drug candidates. Unfortunately, an important factor restricting the utilization of rare sugars is their limited availability, resulting from limited synthetic methods. Nowadays, microbial and enzymatic transformations have become a very powerful tool in this field. This article reviews the biosynthesis and enzymatic production of rare ketohexoses, aldohexoses and sugar alcohols (hexitols), including D-tagatose, D-psicose, D-sorbose, L-tagatose, L-fructose, 1-deoxy-L-fructose, D-allose, L-glucose, L-talose, D-gulose, L-galactose, L-fucose, allitol, D-talitol, and L-sorbitol. New systems and robust catalysts resulting from advancements in genomics and bioengineering are also discussed. |
format | Online Article Text |
id | pubmed-3869271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-38692712013-12-23 Biosynthesis of rare hexoses using microorganisms and related enzymes Li, Zijie Gao, Yahui Nakanishi, Hideki Gao, Xiaodong Cai, Li Beilstein J Org Chem Review Rare sugars, referred to as monosaccharides and their derivatives that rarely exist in nature, can be applied in many areas ranging from foodstuffs to pharmaceutical and nutrition industry, or as starting materials for various natural products and drug candidates. Unfortunately, an important factor restricting the utilization of rare sugars is their limited availability, resulting from limited synthetic methods. Nowadays, microbial and enzymatic transformations have become a very powerful tool in this field. This article reviews the biosynthesis and enzymatic production of rare ketohexoses, aldohexoses and sugar alcohols (hexitols), including D-tagatose, D-psicose, D-sorbose, L-tagatose, L-fructose, 1-deoxy-L-fructose, D-allose, L-glucose, L-talose, D-gulose, L-galactose, L-fucose, allitol, D-talitol, and L-sorbitol. New systems and robust catalysts resulting from advancements in genomics and bioengineering are also discussed. Beilstein-Institut 2013-11-12 /pmc/articles/PMC3869271/ /pubmed/24367410 http://dx.doi.org/10.3762/bjoc.9.281 Text en Copyright © 2013, Li et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
spellingShingle | Review Li, Zijie Gao, Yahui Nakanishi, Hideki Gao, Xiaodong Cai, Li Biosynthesis of rare hexoses using microorganisms and related enzymes |
title | Biosynthesis of rare hexoses using microorganisms and related enzymes |
title_full | Biosynthesis of rare hexoses using microorganisms and related enzymes |
title_fullStr | Biosynthesis of rare hexoses using microorganisms and related enzymes |
title_full_unstemmed | Biosynthesis of rare hexoses using microorganisms and related enzymes |
title_short | Biosynthesis of rare hexoses using microorganisms and related enzymes |
title_sort | biosynthesis of rare hexoses using microorganisms and related enzymes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869271/ https://www.ncbi.nlm.nih.gov/pubmed/24367410 http://dx.doi.org/10.3762/bjoc.9.281 |
work_keys_str_mv | AT lizijie biosynthesisofrarehexosesusingmicroorganismsandrelatedenzymes AT gaoyahui biosynthesisofrarehexosesusingmicroorganismsandrelatedenzymes AT nakanishihideki biosynthesisofrarehexosesusingmicroorganismsandrelatedenzymes AT gaoxiaodong biosynthesisofrarehexosesusingmicroorganismsandrelatedenzymes AT caili biosynthesisofrarehexosesusingmicroorganismsandrelatedenzymes |