Multigramme synthesis and asymmetric dihydroxylation of a 4-fluorobut-2E-enoate

Esters of crotonic acid were brominated on a multigramme scale using a free radical procedure. A phase transfer catalysed fluorination transformed these species to the 4-fluorobut-2E-enoates reproducibly and at scale (48–53%, ca. 300 mmol). Asymmetric dihydroxylation reactions were then used to tran...

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Detalles Bibliográficos
Autores principales: Laurenson, James A B, Parkinson, John A, Percy, Jonathan M, Rinaudo, Giuseppe, Roig, Ricard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869297/
https://www.ncbi.nlm.nih.gov/pubmed/24367430
http://dx.doi.org/10.3762/bjoc.9.301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869297/
https://www.ncbi.nlm.nih.gov/pubmed/24367430
http://dx.doi.org/10.3762/bjoc.9.301

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