Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

2-Chloro-3-amino-4-picoline (CAPIC) is a strategic building block for the preparation of nevirapine, a widely-prescribed non-nucleosidic reverse transcriptase inhibitor for the treatment of HIV-infected patients. A continuous synthesis to the bromo derivative of a CAPIC intermediate, 2-bromo-4-methy...

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Detalles Bibliográficos
Autores principales: Longstreet, Ashley R, Opalka, Suzanne M, Campbell, Brian S, Gupton, B Frank, McQuade, D Tyler
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869350/
https://www.ncbi.nlm.nih.gov/pubmed/24367421
http://dx.doi.org/10.3762/bjoc.9.292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869350/
https://www.ncbi.nlm.nih.gov/pubmed/24367421
http://dx.doi.org/10.3762/bjoc.9.292

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