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Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase

The 26S proteasome is the major eukaryotic ATP-dependent protease, yet the detailed mechanisms utilized by the proteasomal heterohexameric AAA+ unfoldase to drive substrate degradation remain poorly understood. To perform systematic mutational analyses of individual ATPase subunits, we heterologousl...

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Detalles Bibliográficos
Autores principales:	Beckwith, Robyn, Estrin, Eric, Worden, Evan J., Martin, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869383/ https://www.ncbi.nlm.nih.gov/pubmed/24013205 http://dx.doi.org/10.1038/nsmb.2659

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