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A Rev-Independent gag/pol Eliminates Detectable psi-gag Recombination in Lentiviral Vectors
Lentiviral vectors (LVs) are being developed for clinical use in humans for applications including gene therapy and immunotherapy. A safety concern for use of LVs in humans is the generation of replication-competent lentivirus (RCL), which may arise due to recombination between the split genomes of...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Mary Ann Liebert, Inc.
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869434/ https://www.ncbi.nlm.nih.gov/pubmed/24380052 http://dx.doi.org/10.1089/biores.2013.0037 |