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Does excitatory fronto-extracerebral tDCS lead to improved working memory performance?

Evidence suggests that excitatory transcranial direct current stimulation (tDCS) may improve performance on a wide variety of cognitive tasks. Due to the non-invasive and inexpensive nature of the method, harnessing its potential could be particularly useful for the treatment of neuropsychiatric ill...

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Autores principales: Lally, Níall, Nord, Camilla L., Walsh, Vincent, Roiser, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869492/
https://www.ncbi.nlm.nih.gov/pubmed/24555105
http://dx.doi.org/10.12688/f1000research.2-219.v2
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author Lally, Níall
Nord, Camilla L.
Walsh, Vincent
Roiser, Jonathan P.
author_facet Lally, Níall
Nord, Camilla L.
Walsh, Vincent
Roiser, Jonathan P.
author_sort Lally, Níall
collection PubMed
description Evidence suggests that excitatory transcranial direct current stimulation (tDCS) may improve performance on a wide variety of cognitive tasks. Due to the non-invasive and inexpensive nature of the method, harnessing its potential could be particularly useful for the treatment of neuropsychiatric illnesses involving cognitive dysfunction. However, questions remain regarding the efficacious stimulation parameters. Here, using a double-blind between-subjects design, we explored whether 1 mA excitatory (anodal) left dorsolateral prefrontal cortex stimulation with a contralateral extracerebral reference electrode, leads to enhanced working memory performance across two days, relative to sham stimulation. Participants performed the 3-back, a test of working memory, at baseline, and during and immediately following stimulation on two days, separated by 24-48 hours. Active stimulation did not significantly enhance performance versus sham over the course of the experiment. However, exploratory comparisons did reveal a significant effect of stimulation group on performance during the first stimulation phase only, with active stimulation recipients performing better than sham. While these results do not support the hypothesis that dorsolateral prefrontal cortex tDCS boosts working memory, they raise the possibility that its effects may be greatest during early learning stages.
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spelling pubmed-38694922013-12-27 Does excitatory fronto-extracerebral tDCS lead to improved working memory performance? Lally, Níall Nord, Camilla L. Walsh, Vincent Roiser, Jonathan P. F1000Res Research Article Evidence suggests that excitatory transcranial direct current stimulation (tDCS) may improve performance on a wide variety of cognitive tasks. Due to the non-invasive and inexpensive nature of the method, harnessing its potential could be particularly useful for the treatment of neuropsychiatric illnesses involving cognitive dysfunction. However, questions remain regarding the efficacious stimulation parameters. Here, using a double-blind between-subjects design, we explored whether 1 mA excitatory (anodal) left dorsolateral prefrontal cortex stimulation with a contralateral extracerebral reference electrode, leads to enhanced working memory performance across two days, relative to sham stimulation. Participants performed the 3-back, a test of working memory, at baseline, and during and immediately following stimulation on two days, separated by 24-48 hours. Active stimulation did not significantly enhance performance versus sham over the course of the experiment. However, exploratory comparisons did reveal a significant effect of stimulation group on performance during the first stimulation phase only, with active stimulation recipients performing better than sham. While these results do not support the hypothesis that dorsolateral prefrontal cortex tDCS boosts working memory, they raise the possibility that its effects may be greatest during early learning stages. F1000Research 2013-12-10 /pmc/articles/PMC3869492/ /pubmed/24555105 http://dx.doi.org/10.12688/f1000research.2-219.v2 Text en Copyright: © 2013 Lally N et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/publicdomain/zero/1.0/ Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication).
spellingShingle Research Article
Lally, Níall
Nord, Camilla L.
Walsh, Vincent
Roiser, Jonathan P.
Does excitatory fronto-extracerebral tDCS lead to improved working memory performance?
title Does excitatory fronto-extracerebral tDCS lead to improved working memory performance?
title_full Does excitatory fronto-extracerebral tDCS lead to improved working memory performance?
title_fullStr Does excitatory fronto-extracerebral tDCS lead to improved working memory performance?
title_full_unstemmed Does excitatory fronto-extracerebral tDCS lead to improved working memory performance?
title_short Does excitatory fronto-extracerebral tDCS lead to improved working memory performance?
title_sort does excitatory fronto-extracerebral tdcs lead to improved working memory performance?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869492/
https://www.ncbi.nlm.nih.gov/pubmed/24555105
http://dx.doi.org/10.12688/f1000research.2-219.v2
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