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Capecitabine-induced radiation recall phenomenon: a case report

Radiation recall dermatitis is defined as an inflammatory reaction of the skin at the site of previous irradiation. Different drugs have been associated with triggering this phenomenon, and it can also affect other areas and organs where previous radiotherapy has been administered. The time gap betw...

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Autores principales: Aguilar, José, García, Elena, García-Garre, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869495/
https://www.ncbi.nlm.nih.gov/pubmed/24555020
http://dx.doi.org/10.12688/f1000research.1-64.v2
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author Aguilar, José
García, Elena
García-Garre, Elisa
author_facet Aguilar, José
García, Elena
García-Garre, Elisa
author_sort Aguilar, José
collection PubMed
description Radiation recall dermatitis is defined as an inflammatory reaction of the skin at the site of previous irradiation. Different drugs have been associated with triggering this phenomenon, and it can also affect other areas and organs where previous radiotherapy has been administered. The time gap between the inflammatory reaction and previous radiation can range from days to several years. We report a case of capecitabine-induced Radiation Therapy Oncology Group (RTOG) grade 4 (ulcerating dermatitis) recall skin toxicity of skin irradiated 3 years previously. To our knowledge, this is the first reported case of capecitabine-induced RTOG grade 4 (ulcerating dermatitis) recall skin toxicity of previously irradiated skin. Clinicians should be aware of this phenomenon, even when considering patients for whom it has been a long time since previous radiation therapy. This unusual and late drug side effect should be borne in mind in the differential diagnosis and management of advanced-disease patients as it may be confused with local relapse or infectious complication of previously operated areas.
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spelling pubmed-38694952013-12-27 Capecitabine-induced radiation recall phenomenon: a case report Aguilar, José García, Elena García-Garre, Elisa F1000Res Case Report Radiation recall dermatitis is defined as an inflammatory reaction of the skin at the site of previous irradiation. Different drugs have been associated with triggering this phenomenon, and it can also affect other areas and organs where previous radiotherapy has been administered. The time gap between the inflammatory reaction and previous radiation can range from days to several years. We report a case of capecitabine-induced Radiation Therapy Oncology Group (RTOG) grade 4 (ulcerating dermatitis) recall skin toxicity of skin irradiated 3 years previously. To our knowledge, this is the first reported case of capecitabine-induced RTOG grade 4 (ulcerating dermatitis) recall skin toxicity of previously irradiated skin. Clinicians should be aware of this phenomenon, even when considering patients for whom it has been a long time since previous radiation therapy. This unusual and late drug side effect should be borne in mind in the differential diagnosis and management of advanced-disease patients as it may be confused with local relapse or infectious complication of previously operated areas. F1000Research 2013-03-07 /pmc/articles/PMC3869495/ /pubmed/24555020 http://dx.doi.org/10.12688/f1000research.1-64.v2 Text en Copyright: © 2013 Aguilar J et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/publicdomain/zero/1.0/ Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication).
spellingShingle Case Report
Aguilar, José
García, Elena
García-Garre, Elisa
Capecitabine-induced radiation recall phenomenon: a case report
title Capecitabine-induced radiation recall phenomenon: a case report
title_full Capecitabine-induced radiation recall phenomenon: a case report
title_fullStr Capecitabine-induced radiation recall phenomenon: a case report
title_full_unstemmed Capecitabine-induced radiation recall phenomenon: a case report
title_short Capecitabine-induced radiation recall phenomenon: a case report
title_sort capecitabine-induced radiation recall phenomenon: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869495/
https://www.ncbi.nlm.nih.gov/pubmed/24555020
http://dx.doi.org/10.12688/f1000research.1-64.v2
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