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Characterization of Olanzapine-Solid Dispersions

Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug-carrier ratios such as 1 : 1, 1 : 2, 1 : 4, 1 : 6, 1: 8 and 1 : 10 were tried for optimizatio...

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Autores principales: Krishnamoorthy, Venkateskumar, Nagalingam, Arunkumar, Priya Ranjan Prasad, Verma, Parameshwaran, Siva, George, Neema, Kaliyan, Punitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869588/
https://www.ncbi.nlm.nih.gov/pubmed/24363676
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author Krishnamoorthy, Venkateskumar
Nagalingam, Arunkumar
Priya Ranjan Prasad, Verma
Parameshwaran, Siva
George, Neema
Kaliyan, Punitha
author_facet Krishnamoorthy, Venkateskumar
Nagalingam, Arunkumar
Priya Ranjan Prasad, Verma
Parameshwaran, Siva
George, Neema
Kaliyan, Punitha
author_sort Krishnamoorthy, Venkateskumar
collection PubMed
description Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug-carrier ratios such as 1 : 1, 1 : 2, 1 : 4, 1 : 6, 1: 8 and 1 : 10 were tried for optimization. Characterization was done by phase solubility, in-vitro release, saturation solubility, permeation, wettability, XRD and FTIR analysis. Solid dispersions showed higher solubility and an improved drug release profile than the pure drug. Solid dispersion and physical mixture with a drug-polymer ratio of 1 : 10 showed the best release profile in comparison with the other samples. Phase solubility results verified the solubilization effect of the carrier. XRD and NIR analysis confirmed the reduction of crystallinity in the samples. The release study findings were well supported by the results of wettability, saturation solubility and permeability studies. IR analysis substantiated the inertness of the carrier. It was concluded that pregelatinised starch (PGS) and sodium starch glycollate (SSG) could be utilized as effective carriers to improve the aqueous solubility of poorly soluble drugs.
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spelling pubmed-38695882013-12-20 Characterization of Olanzapine-Solid Dispersions Krishnamoorthy, Venkateskumar Nagalingam, Arunkumar Priya Ranjan Prasad, Verma Parameshwaran, Siva George, Neema Kaliyan, Punitha Iran J Pharm Res Original Article Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug-carrier ratios such as 1 : 1, 1 : 2, 1 : 4, 1 : 6, 1: 8 and 1 : 10 were tried for optimization. Characterization was done by phase solubility, in-vitro release, saturation solubility, permeation, wettability, XRD and FTIR analysis. Solid dispersions showed higher solubility and an improved drug release profile than the pure drug. Solid dispersion and physical mixture with a drug-polymer ratio of 1 : 10 showed the best release profile in comparison with the other samples. Phase solubility results verified the solubilization effect of the carrier. XRD and NIR analysis confirmed the reduction of crystallinity in the samples. The release study findings were well supported by the results of wettability, saturation solubility and permeability studies. IR analysis substantiated the inertness of the carrier. It was concluded that pregelatinised starch (PGS) and sodium starch glycollate (SSG) could be utilized as effective carriers to improve the aqueous solubility of poorly soluble drugs. Shaheed Beheshti University of Medical Sciences 2011 /pmc/articles/PMC3869588/ /pubmed/24363676 Text en © 2011 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Krishnamoorthy, Venkateskumar
Nagalingam, Arunkumar
Priya Ranjan Prasad, Verma
Parameshwaran, Siva
George, Neema
Kaliyan, Punitha
Characterization of Olanzapine-Solid Dispersions
title Characterization of Olanzapine-Solid Dispersions
title_full Characterization of Olanzapine-Solid Dispersions
title_fullStr Characterization of Olanzapine-Solid Dispersions
title_full_unstemmed Characterization of Olanzapine-Solid Dispersions
title_short Characterization of Olanzapine-Solid Dispersions
title_sort characterization of olanzapine-solid dispersions
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869588/
https://www.ncbi.nlm.nih.gov/pubmed/24363676
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