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Characterization of Olanzapine-Solid Dispersions
Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug-carrier ratios such as 1 : 1, 1 : 2, 1 : 4, 1 : 6, 1: 8 and 1 : 10 were tried for optimizatio...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869588/ https://www.ncbi.nlm.nih.gov/pubmed/24363676 |
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author | Krishnamoorthy, Venkateskumar Nagalingam, Arunkumar Priya Ranjan Prasad, Verma Parameshwaran, Siva George, Neema Kaliyan, Punitha |
author_facet | Krishnamoorthy, Venkateskumar Nagalingam, Arunkumar Priya Ranjan Prasad, Verma Parameshwaran, Siva George, Neema Kaliyan, Punitha |
author_sort | Krishnamoorthy, Venkateskumar |
collection | PubMed |
description | Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug-carrier ratios such as 1 : 1, 1 : 2, 1 : 4, 1 : 6, 1: 8 and 1 : 10 were tried for optimization. Characterization was done by phase solubility, in-vitro release, saturation solubility, permeation, wettability, XRD and FTIR analysis. Solid dispersions showed higher solubility and an improved drug release profile than the pure drug. Solid dispersion and physical mixture with a drug-polymer ratio of 1 : 10 showed the best release profile in comparison with the other samples. Phase solubility results verified the solubilization effect of the carrier. XRD and NIR analysis confirmed the reduction of crystallinity in the samples. The release study findings were well supported by the results of wettability, saturation solubility and permeability studies. IR analysis substantiated the inertness of the carrier. It was concluded that pregelatinised starch (PGS) and sodium starch glycollate (SSG) could be utilized as effective carriers to improve the aqueous solubility of poorly soluble drugs. |
format | Online Article Text |
id | pubmed-3869588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-38695882013-12-20 Characterization of Olanzapine-Solid Dispersions Krishnamoorthy, Venkateskumar Nagalingam, Arunkumar Priya Ranjan Prasad, Verma Parameshwaran, Siva George, Neema Kaliyan, Punitha Iran J Pharm Res Original Article Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug-carrier ratios such as 1 : 1, 1 : 2, 1 : 4, 1 : 6, 1: 8 and 1 : 10 were tried for optimization. Characterization was done by phase solubility, in-vitro release, saturation solubility, permeation, wettability, XRD and FTIR analysis. Solid dispersions showed higher solubility and an improved drug release profile than the pure drug. Solid dispersion and physical mixture with a drug-polymer ratio of 1 : 10 showed the best release profile in comparison with the other samples. Phase solubility results verified the solubilization effect of the carrier. XRD and NIR analysis confirmed the reduction of crystallinity in the samples. The release study findings were well supported by the results of wettability, saturation solubility and permeability studies. IR analysis substantiated the inertness of the carrier. It was concluded that pregelatinised starch (PGS) and sodium starch glycollate (SSG) could be utilized as effective carriers to improve the aqueous solubility of poorly soluble drugs. Shaheed Beheshti University of Medical Sciences 2011 /pmc/articles/PMC3869588/ /pubmed/24363676 Text en © 2011 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Krishnamoorthy, Venkateskumar Nagalingam, Arunkumar Priya Ranjan Prasad, Verma Parameshwaran, Siva George, Neema Kaliyan, Punitha Characterization of Olanzapine-Solid Dispersions |
title | Characterization of Olanzapine-Solid Dispersions |
title_full | Characterization of Olanzapine-Solid Dispersions |
title_fullStr | Characterization of Olanzapine-Solid Dispersions |
title_full_unstemmed | Characterization of Olanzapine-Solid Dispersions |
title_short | Characterization of Olanzapine-Solid Dispersions |
title_sort | characterization of olanzapine-solid dispersions |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869588/ https://www.ncbi.nlm.nih.gov/pubmed/24363676 |
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