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Agonistic Anti-TIGIT Treatment Inhibits T Cell Responses in LDLr Deficient Mice without Affecting Atherosclerotic Lesion Development

OBJECTIVE: Co-stimulatory and co-inhibitory molecules are mainly expressed on T cells and antigen presenting cells and strongly orchestrate adaptive immune responses. Whereas co-stimulatory molecules enhance immune responses, signaling via co-inhibitory molecules dampens the immune system, thereby s...

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Detalles Bibliográficos
Autores principales:	Foks, Amanda C., Ran, Ingrid A., Frodermann, Vanessa, Bot, Ilze, van Santbrink, Peter J., Kuiper, Johan, van Puijvelde, Gijs H. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869776/ https://www.ncbi.nlm.nih.gov/pubmed/24376654 http://dx.doi.org/10.1371/journal.pone.0083134

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