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Co-Expression of GRK2 Reveals a Novel Conformational State of the µ-Opioid Receptor

Agonists at the µ-opioid receptor are known to produce potent analgesic responses in the clinical setting, therefore, an increased understanding of the molecular interactions of ligands at this receptor could lead to improved analgesics. As historically morphine has been shown to be a poor recruiter...

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Detalles Bibliográficos
Autores principales: Nickolls, Sarah A., Humphreys, Sian, Clark, Mellissa, McMurray, Gordon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869807/
https://www.ncbi.nlm.nih.gov/pubmed/24376730
http://dx.doi.org/10.1371/journal.pone.0083691