Cargando…
Co-Expression of GRK2 Reveals a Novel Conformational State of the µ-Opioid Receptor
Agonists at the µ-opioid receptor are known to produce potent analgesic responses in the clinical setting, therefore, an increased understanding of the molecular interactions of ligands at this receptor could lead to improved analgesics. As historically morphine has been shown to be a poor recruiter...
Autores principales: | Nickolls, Sarah A., Humphreys, Sian, Clark, Mellissa, McMurray, Gordon |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869807/ https://www.ncbi.nlm.nih.gov/pubmed/24376730 http://dx.doi.org/10.1371/journal.pone.0083691 |
Ejemplares similares
-
GRK Mediates μ-Opioid Receptor Plasma Membrane Reorganization
por: Gondin, Arisbel B., et al.
Publicado: (2019) -
Structural heterogeneity of the μ-opioid receptor’s conformational ensemble in the apo state
por: Sena, Diniz M., et al.
Publicado: (2017) -
Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells
por: Møller, Thor C., et al.
Publicado: (2020) -
Antagonistic Roles of GRK2 and GRK5 in Cardiac Aldosterone Signaling Reveal GRK5-Mediated Cardioprotection via Mineralocorticoid Receptor Inhibition
por: Maning, Jennifer, et al.
Publicado: (2020) -
Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy
por: Zhao, Jiawei, et al.
Publicado: (2023)