Up-Regulation of pVHL along with Down-Regulation of HIF-1α by NDRG2 Expression Attenuates Proliferation and Invasion in Renal Cancer Cells

The majority of renal cell carcinomas (RCCs) are characterized by loss of function of the tumor suppressor gene von Hippel Lindau (VHL), which acts as ubiquitin ligase for hypoxia-inducible factor-1α (HIF-1α). In the absence of VHL, HIF-1α protein becomes stabilized and contributes to tumorigenesis....

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Detalles Bibliográficos
Autores principales: Gao, Lei, Wu, Guo-jun, Liu, Bei, Shen, Ming-zhi, Pan, Tie-jun, Yu, Chui-gong, Wang, Qin-hao, Ru, Yi, Liu, Xi-ping, Niu, Tian-shui, Wang, Guo-dong, Wei, Ming, Li, Rui-xiao, Yao, Libo, Wang, He, Li, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869857/
https://www.ncbi.nlm.nih.gov/pubmed/24376788
http://dx.doi.org/10.1371/journal.pone.0084127

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