The Heterotaxy gene, GALNT11, glycosylates Notch to orchestrate cilia type and laterality

Heterotaxy (Htx) is a disorder of left-right (LR) body patterning, or laterality, that is associated with major congenital heart disease(1). The etiology and mechanism underlying most human Htx is poorly understood. In vertebrates, laterality is initiated at the embryonic left-right organizer (LRO),...

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Detalles Bibliográficos
Autores principales: Boskovski, Marko T., Yuan, Shiaulou, Pedersen, Nis Borbye, Goth, Christoffer Knak, Makova, Svetlana, Clausen, Henrik, Brueckner, Martina, Khokha, Mustafa K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869867/
https://www.ncbi.nlm.nih.gov/pubmed/24226769
http://dx.doi.org/10.1038/nature12723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869867/
https://www.ncbi.nlm.nih.gov/pubmed/24226769
http://dx.doi.org/10.1038/nature12723

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