Expression of a Highly Antigenic and Native-Like Folded Extracellular Domain of the Human α1 Subunit of Muscle Nicotinic Acetylcholine Receptor, Suitable for Use in Antigen Specific Therapies for Myasthenia Gravis

We describe the expression of the extracellular domain of the human α1 nicotinic acetylcholine receptor (nAChR) in lepidopteran insect cells (i-α1-ECD) and its suitability for use in antigen-specific therapies for Myasthenia Gravis (MG). Compared to the previously expressed protein in P. pastoris (y...

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Detalles Bibliográficos
Autores principales: Niarchos, Athanasios, Zouridakis, Marios, Douris, Vassilis, Georgostathi, Assimina, Kalamida, Dimitra, Sotiriadis, Alexandros, Poulas, Konstantinos, Iatrou, Kostas, Tzartos, Socrates J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869910/
https://www.ncbi.nlm.nih.gov/pubmed/24376846
http://dx.doi.org/10.1371/journal.pone.0084791

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