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piggyBac Transposon plus Insulators Overcome Epigenetic Silencing to Provide for Stable Signaling Pathway Reporter Cell Lines
Genetically modified hematopoietic progenitors represent an important testing platform for a variety of cell-based therapies, pharmaceuticals, diagnostics and other applications. Stable expression of a transfected gene of interest in the cells is often obstructed by its silencing. DNA transposons of...
Autores principales: | Mossine, Valeri V., Waters, James K., Hannink, Mark, Mawhinney, Thomas P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869926/ https://www.ncbi.nlm.nih.gov/pubmed/24376882 http://dx.doi.org/10.1371/journal.pone.0085494 |
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