RBP2 Induces Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer

RBP2 has been found to actively participate in cancer progression. It inhibits the senescence of cancer cells, mediates cancer cell proliferation and promotes cancer metastasis. It is also essential to drug tolerance. However, the effects of RBP2 on epithelial-mesenchymal transition are still unknow...

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Detalles Bibliográficos
Autores principales: Wang, Shikun, Wang, Yang, Wu, Haijian, Hu, Likuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869927/
https://www.ncbi.nlm.nih.gov/pubmed/24376841
http://dx.doi.org/10.1371/journal.pone.0084735
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author Wang, Shikun
Wang, Yang
Wu, Haijian
Hu, Likuan
author_facet Wang, Shikun
Wang, Yang
Wu, Haijian
Hu, Likuan
author_sort Wang, Shikun
collection PubMed
description RBP2 has been found to actively participate in cancer progression. It inhibits the senescence of cancer cells, mediates cancer cell proliferation and promotes cancer metastasis. It is also essential to drug tolerance. However, the effects of RBP2 on epithelial-mesenchymal transition are still unknown. In this study, we analyzed the effects of RBP2 on epithelial-mesenchymal transition in non-small cell lung cancer. The results showed that RBP2 down-regulated the expression of E-cadherin by inhibiting the promoter activity of E-cadherin and up-regulated the expression of N-cadherin and snail via the activation of Akt signaling, and the overexpression of RBP2 induced epithelial-mesenchymal transition in non-small cell lung cancer cells. Our study further indicated thatRBP2 may be a potential target for anti-lung cancer therapy.
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spelling pubmed-38699272013-12-27 RBP2 Induces Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer Wang, Shikun Wang, Yang Wu, Haijian Hu, Likuan PLoS One Research Article RBP2 has been found to actively participate in cancer progression. It inhibits the senescence of cancer cells, mediates cancer cell proliferation and promotes cancer metastasis. It is also essential to drug tolerance. However, the effects of RBP2 on epithelial-mesenchymal transition are still unknown. In this study, we analyzed the effects of RBP2 on epithelial-mesenchymal transition in non-small cell lung cancer. The results showed that RBP2 down-regulated the expression of E-cadherin by inhibiting the promoter activity of E-cadherin and up-regulated the expression of N-cadherin and snail via the activation of Akt signaling, and the overexpression of RBP2 induced epithelial-mesenchymal transition in non-small cell lung cancer cells. Our study further indicated thatRBP2 may be a potential target for anti-lung cancer therapy. Public Library of Science 2013-12-20 /pmc/articles/PMC3869927/ /pubmed/24376841 http://dx.doi.org/10.1371/journal.pone.0084735 Text en © 2013 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wang, Shikun
Wang, Yang
Wu, Haijian
Hu, Likuan
RBP2 Induces Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer
title RBP2 Induces Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer
title_full RBP2 Induces Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer
title_fullStr RBP2 Induces Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer
title_full_unstemmed RBP2 Induces Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer
title_short RBP2 Induces Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer
title_sort rbp2 induces epithelial-mesenchymal transition in non-small cell lung cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869927/
https://www.ncbi.nlm.nih.gov/pubmed/24376841
http://dx.doi.org/10.1371/journal.pone.0084735
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