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Diagnostic digital cytopathology: Are we ready yet?
BACKGROUND: The cytology literature relating to diagnostic accuracy using whole slide imaging is scarce. We studied the diagnostic concordance between glass and digital slides among diagnosticians with different profiles to assess the readiness of adopting digital cytology in routine practice. MATER...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869956/ https://www.ncbi.nlm.nih.gov/pubmed/24392242 http://dx.doi.org/10.4103/2153-3539.120727 |
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author | House, Jarret C. Henderson-Jackson, Evita B. Johnson, Joseph O. Lloyd, Mark C. Dhillon, Jasreman Ahmad, Nazeel Hakam, Ardeshir Khalbuss, Walid E. Leon, Marino E. Chhieng, David Zhang, Xiaohui Centeno, Barbara A. Bui, Marilyn M. |
author_facet | House, Jarret C. Henderson-Jackson, Evita B. Johnson, Joseph O. Lloyd, Mark C. Dhillon, Jasreman Ahmad, Nazeel Hakam, Ardeshir Khalbuss, Walid E. Leon, Marino E. Chhieng, David Zhang, Xiaohui Centeno, Barbara A. Bui, Marilyn M. |
author_sort | House, Jarret C. |
collection | PubMed |
description | BACKGROUND: The cytology literature relating to diagnostic accuracy using whole slide imaging is scarce. We studied the diagnostic concordance between glass and digital slides among diagnosticians with different profiles to assess the readiness of adopting digital cytology in routine practice. MATERIALS AND METHODS: This cohort consisted of 22 de-identified previously screened and diagnosed cases, including non-gynecological and gynecological slides using standard preparations. Glass slides were digitalized using Aperio ScanScope XT (×20 and ×40). Cytopathologists with (3) and without (3) digital experience, cytotechnologists (4) and senior pathology residents (2) diagnosed the digital slides independently first and recorded the results. Glass slides were read and recorded separately 1-3 days later. Accuracy of diagnosis, time to diagnosis and diagnostician's profile were analyzed. RESULTS: Among 22 case pairs and four study groups, correct diagnosis (93% vs. 86%) was established using glass versus digital slides. Both methods more (>95%) accurately diagnosed positive cases than negatives. Cytopathologists with no digital experience were the most accurate in digital diagnosis, even the senior members. Cytotechnologists had the fastest diagnosis time (3 min/digital vs. 1.7 min/glass), but not the best accuracy. Digital time was 1.5 min longer than glass-slide time/per case for cytopathologists and cytotechnologists. Senior pathology residents were slower and less accurate with both methods. Cytopathologists with digital experience ranked 2(nd) fastest in time, yet last in accuracy for digital slides. CONCLUSIONS: There was good overall diagnostic agreement between the digital whole-slide images and glass slides. Although glass slide diagnosis was more accurate and faster, the results of technologists and pathologists with no digital cytology experience suggest that solid diagnostic ability is a strong indicator for readiness of digital adoption. |
format | Online Article Text |
id | pubmed-3869956 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38699562014-01-03 Diagnostic digital cytopathology: Are we ready yet? House, Jarret C. Henderson-Jackson, Evita B. Johnson, Joseph O. Lloyd, Mark C. Dhillon, Jasreman Ahmad, Nazeel Hakam, Ardeshir Khalbuss, Walid E. Leon, Marino E. Chhieng, David Zhang, Xiaohui Centeno, Barbara A. Bui, Marilyn M. J Pathol Inform Original Article BACKGROUND: The cytology literature relating to diagnostic accuracy using whole slide imaging is scarce. We studied the diagnostic concordance between glass and digital slides among diagnosticians with different profiles to assess the readiness of adopting digital cytology in routine practice. MATERIALS AND METHODS: This cohort consisted of 22 de-identified previously screened and diagnosed cases, including non-gynecological and gynecological slides using standard preparations. Glass slides were digitalized using Aperio ScanScope XT (×20 and ×40). Cytopathologists with (3) and without (3) digital experience, cytotechnologists (4) and senior pathology residents (2) diagnosed the digital slides independently first and recorded the results. Glass slides were read and recorded separately 1-3 days later. Accuracy of diagnosis, time to diagnosis and diagnostician's profile were analyzed. RESULTS: Among 22 case pairs and four study groups, correct diagnosis (93% vs. 86%) was established using glass versus digital slides. Both methods more (>95%) accurately diagnosed positive cases than negatives. Cytopathologists with no digital experience were the most accurate in digital diagnosis, even the senior members. Cytotechnologists had the fastest diagnosis time (3 min/digital vs. 1.7 min/glass), but not the best accuracy. Digital time was 1.5 min longer than glass-slide time/per case for cytopathologists and cytotechnologists. Senior pathology residents were slower and less accurate with both methods. Cytopathologists with digital experience ranked 2(nd) fastest in time, yet last in accuracy for digital slides. CONCLUSIONS: There was good overall diagnostic agreement between the digital whole-slide images and glass slides. Although glass slide diagnosis was more accurate and faster, the results of technologists and pathologists with no digital cytology experience suggest that solid diagnostic ability is a strong indicator for readiness of digital adoption. Medknow Publications & Media Pvt Ltd 2013-10-29 /pmc/articles/PMC3869956/ /pubmed/24392242 http://dx.doi.org/10.4103/2153-3539.120727 Text en Copyright: © 2013 House JC http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Original Article House, Jarret C. Henderson-Jackson, Evita B. Johnson, Joseph O. Lloyd, Mark C. Dhillon, Jasreman Ahmad, Nazeel Hakam, Ardeshir Khalbuss, Walid E. Leon, Marino E. Chhieng, David Zhang, Xiaohui Centeno, Barbara A. Bui, Marilyn M. Diagnostic digital cytopathology: Are we ready yet? |
title | Diagnostic digital cytopathology: Are we ready yet? |
title_full | Diagnostic digital cytopathology: Are we ready yet? |
title_fullStr | Diagnostic digital cytopathology: Are we ready yet? |
title_full_unstemmed | Diagnostic digital cytopathology: Are we ready yet? |
title_short | Diagnostic digital cytopathology: Are we ready yet? |
title_sort | diagnostic digital cytopathology: are we ready yet? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869956/ https://www.ncbi.nlm.nih.gov/pubmed/24392242 http://dx.doi.org/10.4103/2153-3539.120727 |
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