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Posterior insular cortex – a site of vestibular–somatosensory interaction?
Background In previous imaging studies the insular cortex (IC) has been identified as an essential part of the processing of a wide spectrum of perception and sensorimotor integration. Yet, there are no systematic lesion studies in a sufficient number of patients examining whether processing of vest...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Inc
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869980/ https://www.ncbi.nlm.nih.gov/pubmed/24392273 http://dx.doi.org/10.1002/brb3.155 |
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author | Baier, Bernhard zu Eulenburg, Peter Best, Christoph Geber, Christian Müller-Forell, Wibke Birklein, Frank Dieterich, Marianne |
author_facet | Baier, Bernhard zu Eulenburg, Peter Best, Christoph Geber, Christian Müller-Forell, Wibke Birklein, Frank Dieterich, Marianne |
author_sort | Baier, Bernhard |
collection | PubMed |
description | Background In previous imaging studies the insular cortex (IC) has been identified as an essential part of the processing of a wide spectrum of perception and sensorimotor integration. Yet, there are no systematic lesion studies in a sufficient number of patients examining whether processing of vestibular and the interaction of somatosensory and vestibular signals take place in the IC. Methods We investigated acute stroke patients with lesions affecting the IC in order to fill this gap. In detail, we explored signs of a vestibular tone imbalance such as the deviation of the subjective visual vertical (SVV). We applied voxel-lesion behaviour mapping analysis in 27 patients with acute unilateral stroke. Results Our data demonstrate that patients with lesions of the posterior IC have an abnormal tilt of SVV. Furthermore, re-analysing data of 20 patients from a previous study, we found a positive correlation between thermal perception contralateral to the stroke and the severity of the SVV tilt. Conclusions We conclude that the IC is a sensory brain region where different modalities might interact. |
format | Online Article Text |
id | pubmed-3869980 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Blackwell Publishing Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-38699802014-01-03 Posterior insular cortex – a site of vestibular–somatosensory interaction? Baier, Bernhard zu Eulenburg, Peter Best, Christoph Geber, Christian Müller-Forell, Wibke Birklein, Frank Dieterich, Marianne Brain Behav Original Research Background In previous imaging studies the insular cortex (IC) has been identified as an essential part of the processing of a wide spectrum of perception and sensorimotor integration. Yet, there are no systematic lesion studies in a sufficient number of patients examining whether processing of vestibular and the interaction of somatosensory and vestibular signals take place in the IC. Methods We investigated acute stroke patients with lesions affecting the IC in order to fill this gap. In detail, we explored signs of a vestibular tone imbalance such as the deviation of the subjective visual vertical (SVV). We applied voxel-lesion behaviour mapping analysis in 27 patients with acute unilateral stroke. Results Our data demonstrate that patients with lesions of the posterior IC have an abnormal tilt of SVV. Furthermore, re-analysing data of 20 patients from a previous study, we found a positive correlation between thermal perception contralateral to the stroke and the severity of the SVV tilt. Conclusions We conclude that the IC is a sensory brain region where different modalities might interact. Blackwell Publishing Inc 2013-09 2013-07-23 /pmc/articles/PMC3869980/ /pubmed/24392273 http://dx.doi.org/10.1002/brb3.155 Text en © 2013 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. |
spellingShingle | Original Research Baier, Bernhard zu Eulenburg, Peter Best, Christoph Geber, Christian Müller-Forell, Wibke Birklein, Frank Dieterich, Marianne Posterior insular cortex – a site of vestibular–somatosensory interaction? |
title | Posterior insular cortex – a site of vestibular–somatosensory interaction? |
title_full | Posterior insular cortex – a site of vestibular–somatosensory interaction? |
title_fullStr | Posterior insular cortex – a site of vestibular–somatosensory interaction? |
title_full_unstemmed | Posterior insular cortex – a site of vestibular–somatosensory interaction? |
title_short | Posterior insular cortex – a site of vestibular–somatosensory interaction? |
title_sort | posterior insular cortex – a site of vestibular–somatosensory interaction? |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869980/ https://www.ncbi.nlm.nih.gov/pubmed/24392273 http://dx.doi.org/10.1002/brb3.155 |
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