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Early Intervention with High-Dose Steroid Pulse Therapy Prolongs Disease-Free Interval of Severe Alopecia Areata: A Retrospective Study
BACKGROUND: Spontaneous recovery of severe alopecia areata is rare and the condition is difficult to treat. OBJECTIVE: The aim of this study is to investigate and compare the effects and safety of steroid pulse therapy between oral and intravenous administrations between 1999 and 2010 at the Departm...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Dermatological Association; The Korean Society for Investigative Dermatology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870216/ https://www.ncbi.nlm.nih.gov/pubmed/24371395 http://dx.doi.org/10.5021/ad.2013.25.4.471 |
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author | Yang, Chao-Chun Lee, Chun-Te Hsu, Chao-Kai Lee, Yi-Pei Wong, Tak-Wah Chao, Sheau-Chiou Lee, Julia Yu-Yun Sheu, Hamm-Ming Chen, WenChieh |
author_facet | Yang, Chao-Chun Lee, Chun-Te Hsu, Chao-Kai Lee, Yi-Pei Wong, Tak-Wah Chao, Sheau-Chiou Lee, Julia Yu-Yun Sheu, Hamm-Ming Chen, WenChieh |
author_sort | Yang, Chao-Chun |
collection | PubMed |
description | BACKGROUND: Spontaneous recovery of severe alopecia areata is rare and the condition is difficult to treat. OBJECTIVE: The aim of this study is to investigate and compare the effects and safety of steroid pulse therapy between oral and intravenous administrations between 1999 and 2010 at the Department of Dermatology, National Cheng Kung University Hospital. METHODS: Data were retrospectively retrieved. A satisfactory response was defined as more than 75% hair regrowth in the balding area. RESULTS: A total of 85 patients with more than 50% hair loss were identified and treated, with an overall satisfactory response rate of 51.8%. The mean follow-up time was 37.6 months, with a relapse rate of 22.7%. Patients with alopecia areata (hereafter, AA) of recent onset within one year showed higher response rates (p<0.001) and lower relapse rates compared to patients with AA persisting for more than 1 year. Further, even in patients with alopecia totalis, alopecia universalis or ophiasis type, early treatment resulted in a satisfactory response rate of 47% among the treated patients. In general, oral therapy was as effective and well-tolerated as intravenous therapy. CONCLUSION: The response rate is determined by disease severity and time of intervention, not by the administration form of steroid pulse therapy. Oral steroid pulse therapy can be considered as the first-line treatment for patients with severe AA of recent onset within one year. |
format | Online Article Text |
id | pubmed-3870216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Korean Dermatological Association; The Korean Society for Investigative Dermatology |
record_format | MEDLINE/PubMed |
spelling | pubmed-38702162013-12-26 Early Intervention with High-Dose Steroid Pulse Therapy Prolongs Disease-Free Interval of Severe Alopecia Areata: A Retrospective Study Yang, Chao-Chun Lee, Chun-Te Hsu, Chao-Kai Lee, Yi-Pei Wong, Tak-Wah Chao, Sheau-Chiou Lee, Julia Yu-Yun Sheu, Hamm-Ming Chen, WenChieh Ann Dermatol Original Article BACKGROUND: Spontaneous recovery of severe alopecia areata is rare and the condition is difficult to treat. OBJECTIVE: The aim of this study is to investigate and compare the effects and safety of steroid pulse therapy between oral and intravenous administrations between 1999 and 2010 at the Department of Dermatology, National Cheng Kung University Hospital. METHODS: Data were retrospectively retrieved. A satisfactory response was defined as more than 75% hair regrowth in the balding area. RESULTS: A total of 85 patients with more than 50% hair loss were identified and treated, with an overall satisfactory response rate of 51.8%. The mean follow-up time was 37.6 months, with a relapse rate of 22.7%. Patients with alopecia areata (hereafter, AA) of recent onset within one year showed higher response rates (p<0.001) and lower relapse rates compared to patients with AA persisting for more than 1 year. Further, even in patients with alopecia totalis, alopecia universalis or ophiasis type, early treatment resulted in a satisfactory response rate of 47% among the treated patients. In general, oral therapy was as effective and well-tolerated as intravenous therapy. CONCLUSION: The response rate is determined by disease severity and time of intervention, not by the administration form of steroid pulse therapy. Oral steroid pulse therapy can be considered as the first-line treatment for patients with severe AA of recent onset within one year. Korean Dermatological Association; The Korean Society for Investigative Dermatology 2013-11 2013-11-30 /pmc/articles/PMC3870216/ /pubmed/24371395 http://dx.doi.org/10.5021/ad.2013.25.4.471 Text en Copyright © 2013 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yang, Chao-Chun Lee, Chun-Te Hsu, Chao-Kai Lee, Yi-Pei Wong, Tak-Wah Chao, Sheau-Chiou Lee, Julia Yu-Yun Sheu, Hamm-Ming Chen, WenChieh Early Intervention with High-Dose Steroid Pulse Therapy Prolongs Disease-Free Interval of Severe Alopecia Areata: A Retrospective Study |
title | Early Intervention with High-Dose Steroid Pulse Therapy Prolongs Disease-Free Interval of Severe Alopecia Areata: A Retrospective Study |
title_full | Early Intervention with High-Dose Steroid Pulse Therapy Prolongs Disease-Free Interval of Severe Alopecia Areata: A Retrospective Study |
title_fullStr | Early Intervention with High-Dose Steroid Pulse Therapy Prolongs Disease-Free Interval of Severe Alopecia Areata: A Retrospective Study |
title_full_unstemmed | Early Intervention with High-Dose Steroid Pulse Therapy Prolongs Disease-Free Interval of Severe Alopecia Areata: A Retrospective Study |
title_short | Early Intervention with High-Dose Steroid Pulse Therapy Prolongs Disease-Free Interval of Severe Alopecia Areata: A Retrospective Study |
title_sort | early intervention with high-dose steroid pulse therapy prolongs disease-free interval of severe alopecia areata: a retrospective study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870216/ https://www.ncbi.nlm.nih.gov/pubmed/24371395 http://dx.doi.org/10.5021/ad.2013.25.4.471 |
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