Cargando…

MicroRNAs in sensorineural diseases of the ear

Non-coding microRNAs (miRNAs) have a fundamental role in gene regulation and expression in almost every multicellular organism. Only discovered in the last decade, miRNAs are already known to play a leading role in many aspects of disease. In the vertebrate inner ear, miRNAs are essential for contro...

Descripción completa

Detalles Bibliográficos
Autores principales: Ushakov, Kathy, Rudnicki, Anya, Avraham, Karen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870287/
https://www.ncbi.nlm.nih.gov/pubmed/24391537
http://dx.doi.org/10.3389/fnmol.2013.00052
_version_ 1782296687103967232
author Ushakov, Kathy
Rudnicki, Anya
Avraham, Karen B.
author_facet Ushakov, Kathy
Rudnicki, Anya
Avraham, Karen B.
author_sort Ushakov, Kathy
collection PubMed
description Non-coding microRNAs (miRNAs) have a fundamental role in gene regulation and expression in almost every multicellular organism. Only discovered in the last decade, miRNAs are already known to play a leading role in many aspects of disease. In the vertebrate inner ear, miRNAs are essential for controlling development and survival of hair cells. Moreover, dysregulation of miRNAs has been implicated in sensorineural hearing impairment, as well as in other ear diseases such as cholesteatomas, vestibular schwannomas, and otitis media. Due to the inaccessibility of the ear in humans, animal models have provided the optimal tools to study miRNA expression and function, in particular mice and zebrafish. A major focus of current research has been to discover the targets of the miRNAs expressed in the inner ear, in order to determine the regulatory pathways of the auditory and vestibular systems. The potential for miRNAs manipulation in development of therapeutic tools for hearing impairment is as yet unexplored, paving the way for future work in the field.
format Online
Article
Text
id pubmed-3870287
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-38702872014-01-03 MicroRNAs in sensorineural diseases of the ear Ushakov, Kathy Rudnicki, Anya Avraham, Karen B. Front Mol Neurosci Neuroscience Non-coding microRNAs (miRNAs) have a fundamental role in gene regulation and expression in almost every multicellular organism. Only discovered in the last decade, miRNAs are already known to play a leading role in many aspects of disease. In the vertebrate inner ear, miRNAs are essential for controlling development and survival of hair cells. Moreover, dysregulation of miRNAs has been implicated in sensorineural hearing impairment, as well as in other ear diseases such as cholesteatomas, vestibular schwannomas, and otitis media. Due to the inaccessibility of the ear in humans, animal models have provided the optimal tools to study miRNA expression and function, in particular mice and zebrafish. A major focus of current research has been to discover the targets of the miRNAs expressed in the inner ear, in order to determine the regulatory pathways of the auditory and vestibular systems. The potential for miRNAs manipulation in development of therapeutic tools for hearing impairment is as yet unexplored, paving the way for future work in the field. Frontiers Media S.A. 2013-12-23 /pmc/articles/PMC3870287/ /pubmed/24391537 http://dx.doi.org/10.3389/fnmol.2013.00052 Text en Copyright © 2013 Ushakov, Rudnicki and Avraham. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ushakov, Kathy
Rudnicki, Anya
Avraham, Karen B.
MicroRNAs in sensorineural diseases of the ear
title MicroRNAs in sensorineural diseases of the ear
title_full MicroRNAs in sensorineural diseases of the ear
title_fullStr MicroRNAs in sensorineural diseases of the ear
title_full_unstemmed MicroRNAs in sensorineural diseases of the ear
title_short MicroRNAs in sensorineural diseases of the ear
title_sort micrornas in sensorineural diseases of the ear
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870287/
https://www.ncbi.nlm.nih.gov/pubmed/24391537
http://dx.doi.org/10.3389/fnmol.2013.00052
work_keys_str_mv AT ushakovkathy micrornasinsensorineuraldiseasesoftheear
AT rudnickianya micrornasinsensorineuraldiseasesoftheear
AT avrahamkarenb micrornasinsensorineuraldiseasesoftheear