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MicroRNAs in sensorineural diseases of the ear
Non-coding microRNAs (miRNAs) have a fundamental role in gene regulation and expression in almost every multicellular organism. Only discovered in the last decade, miRNAs are already known to play a leading role in many aspects of disease. In the vertebrate inner ear, miRNAs are essential for contro...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870287/ https://www.ncbi.nlm.nih.gov/pubmed/24391537 http://dx.doi.org/10.3389/fnmol.2013.00052 |
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author | Ushakov, Kathy Rudnicki, Anya Avraham, Karen B. |
author_facet | Ushakov, Kathy Rudnicki, Anya Avraham, Karen B. |
author_sort | Ushakov, Kathy |
collection | PubMed |
description | Non-coding microRNAs (miRNAs) have a fundamental role in gene regulation and expression in almost every multicellular organism. Only discovered in the last decade, miRNAs are already known to play a leading role in many aspects of disease. In the vertebrate inner ear, miRNAs are essential for controlling development and survival of hair cells. Moreover, dysregulation of miRNAs has been implicated in sensorineural hearing impairment, as well as in other ear diseases such as cholesteatomas, vestibular schwannomas, and otitis media. Due to the inaccessibility of the ear in humans, animal models have provided the optimal tools to study miRNA expression and function, in particular mice and zebrafish. A major focus of current research has been to discover the targets of the miRNAs expressed in the inner ear, in order to determine the regulatory pathways of the auditory and vestibular systems. The potential for miRNAs manipulation in development of therapeutic tools for hearing impairment is as yet unexplored, paving the way for future work in the field. |
format | Online Article Text |
id | pubmed-3870287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-38702872014-01-03 MicroRNAs in sensorineural diseases of the ear Ushakov, Kathy Rudnicki, Anya Avraham, Karen B. Front Mol Neurosci Neuroscience Non-coding microRNAs (miRNAs) have a fundamental role in gene regulation and expression in almost every multicellular organism. Only discovered in the last decade, miRNAs are already known to play a leading role in many aspects of disease. In the vertebrate inner ear, miRNAs are essential for controlling development and survival of hair cells. Moreover, dysregulation of miRNAs has been implicated in sensorineural hearing impairment, as well as in other ear diseases such as cholesteatomas, vestibular schwannomas, and otitis media. Due to the inaccessibility of the ear in humans, animal models have provided the optimal tools to study miRNA expression and function, in particular mice and zebrafish. A major focus of current research has been to discover the targets of the miRNAs expressed in the inner ear, in order to determine the regulatory pathways of the auditory and vestibular systems. The potential for miRNAs manipulation in development of therapeutic tools for hearing impairment is as yet unexplored, paving the way for future work in the field. Frontiers Media S.A. 2013-12-23 /pmc/articles/PMC3870287/ /pubmed/24391537 http://dx.doi.org/10.3389/fnmol.2013.00052 Text en Copyright © 2013 Ushakov, Rudnicki and Avraham. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Ushakov, Kathy Rudnicki, Anya Avraham, Karen B. MicroRNAs in sensorineural diseases of the ear |
title | MicroRNAs in sensorineural diseases of the ear |
title_full | MicroRNAs in sensorineural diseases of the ear |
title_fullStr | MicroRNAs in sensorineural diseases of the ear |
title_full_unstemmed | MicroRNAs in sensorineural diseases of the ear |
title_short | MicroRNAs in sensorineural diseases of the ear |
title_sort | micrornas in sensorineural diseases of the ear |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870287/ https://www.ncbi.nlm.nih.gov/pubmed/24391537 http://dx.doi.org/10.3389/fnmol.2013.00052 |
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