Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer’s Disease

One of the characteristic hallmarks of Alzheimer’s disease (AD) is an accumulation of amyloid β (Aβ) leading to plaque formation and toxic oligomeric Aβ complexes. Besides the de novo synthesis of Aβ caused by amyloidogenic processing of the amyloid precursor protein (APP), Aβ levels are also highly...

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Detalles Bibliográficos
Autores principales: Grimm, Marcus O. W., Mett, Janine, Stahlmann, Christoph P., Haupenthal, Viola J., Zimmer, Valerie C., Hartmann, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870290/
https://www.ncbi.nlm.nih.gov/pubmed/24391587
http://dx.doi.org/10.3389/fnagi.2013.00098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870290/
https://www.ncbi.nlm.nih.gov/pubmed/24391587
http://dx.doi.org/10.3389/fnagi.2013.00098

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